grant
SARS-CoV-2 initiation and acceleration of AD pathology in the setting of endogenous and exogenous risk factors
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV variant2019-nCoV variant forms2019-nCoV variant strainsAD dementiaAD modelAD pathologyAD related dementiaADRDAPOEAPOE e4APOE-ε4APOEε4AccelerationAcidsAcute NasopharyngitisAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAmyloidAmyloid A4 Protein PrecursorAmyloid Protein PrecursorAmyloid SubstanceAmyloid beta-Protein PrecursorAmyloid β-Protein PrecursorApo-EApoE proteinApolipoprotein EAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2B.1.617.2BCDFBSF-2BSF2COVID-19COVID-19 affectedCOVID-19 consequenceCOVID-19 effectCOVID-19 impactCOVID-19 impactedCOVID-19 variantCOVID-19 variant formsCOVID-19 variant strainsCOVID-19 virusCOVID19 virusCV-19Cell Communication and SignalingCell SignalingCoV-2CoV2CodeCoding SystemCommon ColdComplexCoronaviridaeCoronavirusCoronavirus Infectious Disease 2019CoupledDelta variantDevelopmentDiseaseDisorderExerciseFamilial diseaseGenesHCoVHPGFHSV-1HSV1Hepatocyte-Stimulating FactorHerpes Simplex Type 1Herpes Simplex Virus 1Herpes Simplex Virus Type 1Herpesvirus 1HistopathologyHistoryHybridoma Growth FactorIFNIFN-beta 2IFNB2IL-1IL-6IL1IL6 ProteinImageImpairmentInflammatoryInterferonsInterleukin IInterleukin-1Interleukin-6Intermediary MetabolismIntracellular Communication and SignalingLinkLobar Atrophy of the BrainLymphocyte-Stimulating HormoneMAPT geneMAPT proteinMGI-2MR ImagingMR TomographyMRIMRIsMT-bound tauMTBT1Macrophage Cell FactorMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMemory LossMetabolic ProcessesMetabolismMethodologyMethodsModelingMyeloid Differentiation-Inducing ProteinNINDSNMR ImagingNMR TomographyNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNeurofibrillary TanglesNuclear Magnetic Resonance ImagingOrthocoronavirinaePSEN1PathologyPathway interactionsPhenotypePick Disease of the BrainPick's DiseasePlasmacytoma Growth FactorPrimary Senile Degenerative DementiaProcessPsyche structureRecording of previous eventsReportingRiskRisk FactorsRoleS182 proteinSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 B.1.617.2SARS-CoV-2 deltaSARS-CoV-2 variantSARS-CoV-2 variant formsSARS-CoV-2 variant strainsSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Severity of illnessSignal TransductionSignal Transduction SystemsSignalingStudy modelsT Helper FactorTauopathiesTestingTransgenic MiceViralVirusWorkWuhan coronavirusZeugmatographyalzheimer modelamyloid precursor proteinapo E-4apo E4apo epsilon4apoE epsilon 4apoE-4apoE4apolipoprotein E epsilon 4apolipoprotein E-4apolipoprotein E4biological signal transductionbrain fogcorona viruscoronavirus disease 2019coronavirus disease 2019 consequencecoronavirus disease 2019 effectcoronavirus disease 2019 impactcoronavirus disease 2019 variantcoronavirus disease 2019 variant formscoronavirus disease 2019 variant strainscoronavirus disease 2019 viruscoronavirus disease-19coronavirus disease-19 impactcoronavirus disease-19 viruscoronavirus infectious disease-19cytokinedevelopmentaldisease modeldisease severitydisorder modeldrivingexperiencefamilial disorderhCoV19herpes simplex iherpes simplex-1historieshuman CoVhuman corona virushuman coronavirushyper-phosphorylated tauhyperphosphorylated tauimagingimaging in vivoin vivo imaginginsightinterferon beta 2lymphocyte activating factormemory declinementalmicrotubule associated protein taumicrotubule bound taumicrotubule-associated protein taumicrotubule-bound taumouse modelmurine modelnCoV2neurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologynovelpathwaypost-COVIDpost-COVID-19post-coronavirus disease 2019presenilin 1 proteinpresenilin-1primary degenerative dementiaresponsesenile dementia of the Alzheimer typesevere acute respiratory syndrome coronavirus 2 B.1.617.2severe acute respiratory syndrome coronavirus 2 variantsevere acute respiratory syndrome coronavirus 2 variant formssevere acute respiratory syndrome coronavirus 2 variant strainssocial roletangletautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytheoriestranscriptomicsτ Proteins
Description preview
The uncertain etiology of Alzheimer’s disease poses significant obstacles to the development of both therapeutic and prevention strategies. At the root of this quandary is the fact that familial disease accounts for a very small fraction of cases, with the vast majority remaining genetically sporadic. The most widely known risk factor, the ApoE4…
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