grant
SARS-CoV-2 infection of non-human primates
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20251,2-Dehydrohydrocortisone18-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucose2019 novel corona virus2019 novel coronavirus2019-nCoVAcuteAnimalsAutopsyB.1.617.2BloodBlood EosinophilBlood Reticuloendothelial SystemCAT scanCOVID disease severityCOVID infected patientCOVID patientCOVID positive patientCOVID severityCOVID-19COVID-19 disease severityCOVID-19 infected patientCOVID-19 infectionCOVID-19 patientCOVID-19 positive patientCOVID-19 severityCOVID-19 virusCOVID-19 virus infectionCOVID19 disease severityCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 severityCOVID19 virusCT X RayCT XrayCT imagingCT scanCV-19ClinicalCoV-2CoV2Computed TomographyCoronavirus Infectious Disease 2019Delta HepatitisDelta InfectionDelta variantDelta(1)HydrocortisoneDelta-FDelta1-dehydro-hydrocortisoneDeltahydrocortisoneDendritic CellsDexamethasoneDiseaseDisease OutcomeDisease ProgressionDisorderEosinophilic GranulocyteEosinophilic LeukocyteFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGamma-delta T cellsGlucocorticoidsGoalsHepatitis DHost resistanceImmuneImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentIndividualInfectionInflammatory ResponseLungLung DiseasesLung InflammationLung Respiratory SystemM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMarrow EosinophilMeasuresMechanical ventilationMediatingMetacortandraloneModelingPET/CTPET/CT scanPathologyPneumonitisPrednisolonumPulmonary DiseasesPulmonary DisorderPulmonary InflammationResistanceResolutionRhesus MacaqueRhesus MonkeySARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 B.1.617.2SARS-CoV-2 deltaSARS-CoV-2 disease severitySARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 severitySARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2TestingTomodensitometryVeiled CellsViralViral BurdenViral LoadViral Load resultViral SheddingVirusVirus SheddingWuhan coronavirusX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectioncatscancell imagingcellular imagingcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographyconfocal imagingcoronavirus disease 2019coronavirus disease 2019 disease severitycoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 severitycoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease severitycoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientdeath riskdisease of the lungdisorder of the lungeosinophilexperimentexperimental researchexperimental studyexperimentsflow cytophotometryfluorodeoxyglucosefollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionhCoV19host responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2life-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lung disordermechanical respiratory assistmechanically ventilatedmortalitymortality risknCoV2necropsynon-contrast CTnon-human primatenoncontrast CTnoncontrast computed tomographynonhuman primatepatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2positron emission computed tomographypost SARS-CoV-2 infectionpostmortemprednisolonepreventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionresistantresolutionsrespiratoryscRNA sequencingscRNA-seqserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 B.1.617.2severe acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 severitysevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingγδ T cellsγδT cells
Description preview
SARS-CoV-2 infection has a spectrum of clinical disease outcomes, ranging from asymptomatic to fatal. The severity of COVID-19 is largely determined by the degree of virus-induced damage and immune-mediated pathology. However, the factors that prevent or promote pulmonary inflammation during SARS-CoV-2 infection are not well understood. Rhesus…
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