grant
SARS-CoV-2 in Pregnancy: Comparison of Natural Infection and Hybrid Immunity in Mother-Infant Pairs
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 5 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike protein2019-nCoV vaccine21+ years old7S Gamma GlobulinAdultAdult HumanAge MonthsAssayBioassayBiological AssayBirthCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID complicationsCOVID diagnosisCOVID disease severityCOVID related complicationsCOVID severityCOVID-19COVID-19 S proteinCOVID-19 antibodyCOVID-19 complicationsCOVID-19 diagnosisCOVID-19 disease severityCOVID-19 infectionCOVID-19 related complicationsCOVID-19 severityCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 therapyCOVID-19 treatmentCOVID-19 vaccineCOVID-19 virusCOVID-19 virus infectionCOVID19 diagnosisCOVID19 disease severityCOVID19 infectionCOVID19 severityCOVID19 virusCV-19ChildhoodClinicalCoV-2CoV2Communicable DiseasesCoronavirus Infectious Disease 2019DataDiagnosisDiscipline of obstetricsDiseaseDisorderELISAEnvelope ProteinEnzyme-Linked Immunosorbent AssayFetal healthFoundationsFundingFutureGestationHybridsIFN-GammaIFN-gIFN-γIFNGIFNγIgGImmuneImmune InterferonImmune responseImmunesImmunityImmunoglobulin GImmunologyImmunomodulationInfantInfectionInfectious DiseasesInfectious DisorderInflammatoryInflammatory ResponseInterdisciplinary ResearchInterdisciplinary StudyInterferon GammaInterferon Type IIInvestigatorsKnowledgeLifeLiteratureLong-term cohortLongitudinal cohortMaternal HealthMeasuresMentorsMentorshipMessenger RNAMothersMultidisciplinary CollaborationMultidisciplinary ResearchNational Institutes of HealthNeonatalNeutralization TestsNucleocapsidObstetricsOnly ChildOutcomePBMCParticipantParturitionPassive ImmunityPerinatalPerinatal InfectionPeripartumPeripheral Blood Mononuclear CellPhasePopulationPostpartum PeriodPregnancyPregnant WomenPrevalenceProteinsRNA immunizationRNA vaccinationRecommendationRecordsResearch PersonnelResearchersRiskRisk FactorsRoleSARS 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acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome coronavirus 2 vaccineSevere acute respiratory syndrome related corona virus 2SiteSocietiesT cell responseT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTherapeuticTimeTranslatingUnited States National Institutes of HealthVaccinationVaccination acquired immunityVaccination induced immunityVaccinesViralViral DiseasesVirus DiseasesWuhan coronavirusadulthoodafter COVID-19 infectionafter SARS-CoV-2 infectionafter SARS-CoV2 infectionafter infection by SARS-CoV-2after severe acute respiratory distress syndrome CoV-2 infectionantibody against COVID-19antibody against SARS-CoV-2antibody against coronavirus disease 2019antibody against severe acute respiratory syndrome coronavirus 2antibody neutralization testantibody to COVID-19antibody to SARS-CoV-2antibody to coronavirus disease 2019antibody to severe acute respiratory syndrome coronavirus 2biomarker developmentbiomarker identificationcareercomplications due to COVID-19coronavirus diagnosiscoronavirus disease 2019coronavirus disease 2019 S proteincoronavirus disease 2019 antibodycoronavirus disease 2019 diagnosiscoronavirus disease 2019 disease severitycoronavirus disease 2019 infectioncoronavirus disease 2019 severitycoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 vaccinecoronavirus disease 2019 viruscoronavirus disease diagnosiscoronavirus disease severitycoronavirus disease-19coronavirus disease-19 vaccinecoronavirus disease-19 viruscoronavirus infectious disease-19cytokinedevelop a vaccinedevelop vaccinesdevelopment of a vaccinediagnosed with COVIDdiagnosed with COVID-19diagnosed with COVID19diagnosed with SARS-CoV-2diagnosed with coronavirusdiagnosed with coronavirus 2019diagnosed with coronavirus diseasediagnosed with coronavirus disease 2019emergent virusemerging pathogenemerging virusenv Antigensenv Gene Productsenv Polyproteinsenv Proteinenzyme linked immunoassayexpectant motherexpectant womenexpecting motherexpecting womenfollowing COVID-19 infectionfollowing SARS-CoV-2 infectionfollowing SARS-CoV2 infectionfollowing infection by SARS-CoV-2following severe acute respiratory distress syndrome CoV-2 infectionhCoV19host responseidentification of biomarkersidentification of new biomarkersimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedindividuals who are pregnantinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2insightlFN-GammamRNAmRNA immunizationmRNA vaccinationmarker identificationmaternal morbiditymaternal outcomematernal riskmother outcomenCoV vaccinenCoV-19 vaccinenCoV19 vaccinenCoV2neonatal healthneonateneutralizing antibodynew pathogennewborn healthnovel pathogenpandemicpandemic diseasepathogenic viruspediatricpeople who are pregnantplacental transferpost SARS-CoV-2 infectionpost-partumpost-partum complicationspostpartum complicationspregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprevious COVID-19 infectionprevious SARS-CoV-2 infectionprevious SARS-CoV2 infectionprevious severe acute respiratory distress syndrome CoV-2 infectionprior COVID-19 infectionprior SARS-CoV-2 infectionprior SARS-CoV2 infectionprior severe acute respiratory distress syndrome CoV-2 infectionreceptor bindingreceptor boundresponserisk stratificationsevere acute respiratory syndrome coronavirus 2 antibodysevere acute respiratory syndrome coronavirus 2 diagnosissevere acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentskillssocial rolesocio-demographicssociodemographicsspike proteins on SARS-CoV-2stemstratify risksystemic inflammationsystemic inflammatory responsetherapeutic agent developmenttherapeutic developmentthose who are pregnantthymus derived lymphocytetranslational cliniciantranslational physiciantreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2treatment guidelinesvaccine acquired immunityvaccine against 2019-nCovvaccine against COVID-19vaccine against SARS-CoV-2vaccine against SARS-coronavirus-2vaccine against Severe Acute Respiratory Syndrome CoV 2vaccine against Severe acute respiratory syndrome coronavirus 2vaccine associated immunityvaccine candidates against SARS-CoV-2vaccine developmentvaccine for novel coronavirusvaccine strategyvaccine-induced immunityvaccine-induced protectionvaccines preventing COVIDvaccines to prevent COVIDviral emergenceviral infectionviral pathogenvirus infectionvirus pathogenvirus-induced diseasewomen who are pregnant
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PROJECT SUMMARY/ABSTRACT
While the clinical spectrum of SARS-CoV-2 infection in pregnancy ranges from asymptomatic to critical disease,
pregnancy itself augments the risk of severe and critical COVID-19. The leading obstetrical societies in the U.S.
recommend COVID-19 messenger RNA (mRNA) vaccination in pregnancy to prevent severe disease.…
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