grant
Salmonella Host interactions
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 Jun 1999Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY2025Abdominal TyphusActive OxygenAddressAnimal ModelAnimal Models and Related StudiesAntibodiesBlood NeutrophilBlood Polymorphonuclear NeutrophilBody TissuesCell BodyCell CycleCell Division CycleCellsCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Enteric FeverGastroenteritisGlycansGoalsHealthHumanImmune EvasionInfectionInvestigatorsKnowledgeLiverMacrophageMarrow NeutrophilMediatingMiceMice MammalsModelingModern ManMolecularMucosaMucosal TissueMucous MembraneMurineMusMφNeutrophilic GranulocyteNeutrophilic LeukocyteOralOxygen RadicalsPathogenesisPathogenicity FactorsPathogenicity IslandPerforationPhagocytosisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPolysaccharidesPro-OxidantsProcessReactive Oxygen SpeciesResearch PersonnelResearchersRoleRouteS enterica serovar TyphiS typhiS typhosaS. enterica serovar TyphiS. typhiS. typhosaSalmonellaSalmonella enterica serovar TyphiSalmonella typhiSalmonella typhosaSpleenSpleen Reticuloendothelial SystemT3SSTestingTissuesType III Secretion SystemType III Secretion System PathwayTyphoidTyphoid FeverUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionVacuoleVirulenceVirulence FactorsWorkexpectationexperimentexperimental researchexperimental studyexperimentsextensive drug resistanceextensively drug resistantextreme drug resistancehepatic body systemhepatic organ systemhuman diseaseimmune evasivein vivoinnovateinnovationinnovativemodel of animalmouse modelmurine modelneutrophilnon-typhoid Salmonellanon-typhoidal Salmonellapathogenresponsesocial roletype 3 secretion system
Description preview
ABSTRACT
Typhoid fever, caused by Salmonella enterica serovar (S.) Typhi, is a major human
disease responsible for 21.6 million illnesses annually. The emergence of extensively drug-
resistant S. Typhi strains in 2016 represents a serious threat to human health according to the
Centers for Disease Control and Prevention (CDC). However, virulence…
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