grant
Safety of Anti-CGRP Migraine Therapeutics in Ischemic Stroke
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 3 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20252-photon microscopyAddressAgeAgingAnimalsApoplexyArteriesAutoregulationBBB penetrationBlood VesselsBrain TIABrain VascularBrain Vascular AccidentCGRP ReceptorsCalcitonin Gene-Related PeptideCalcitonin-Gene Related Peptide ReceptorCardiac infarctionCase StudyCerebral IschemiaCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCerebrumChronicClassic MigraineClassical MigraineClinical Treatment MoabClinical TrialsCommon Rat StrainsConflict of InterestDataDefectDiabetes MellitusDistalDoppler OCTDoseDrug IndustryDrugsDysfunctionEventExclusionFamilial Hemiplegic MigraineFemaleFlowmetryFunctional disorderFundingFutureGoalsHandHomeostasisHypertensionImaging DeviceImaging InstrumentImaging ToolImpairmentIndustryInfarctionIschemiaIschemic StrokeKI miceKnock-in MouseLaboratoriesLaser ElectromagneticLaser RadiationLasersMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMethodsMiceMice MammalsMiddle Cerebral Artery OcclusionMigraineMigraine HeadacheMigraine with AuraMigraine with Typical AuraMissionModelingMonoclonal AntibodiesMurineMusMyocardial InfarctMyocardial InfarctionNMR ImagingNMR TomographyNational Institutes of HealthNeurologic DeficitNuclear Magnetic Resonance ImagingOCT TomographyOptical Coherence TomographyOutcomePatientsPenetrationPerfusionPharmaceutic IndustryPharmaceutical IndustryPharmaceutical PreparationsPhysiological HomeostasisPhysiopathologyPositionPositioning AttributePreclinical dataProphylactic treatmentProphylaxisRatRats MammalsRattusReportingReproducibilityResearchRiskRisk FactorsSafetyStrokeStructureTarget PopulationsTestingTherapeuticTransient Ischemic AttackTrustUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderVasodilatationVasodilating AgentVasodilationVasodilator AgentsVasodilator DrugsVasodilatorsVasorelaxationWorkZeugmatographyagedagesantagonismantagonistarmblood flow in brainblood-brain barrier penetrationbloodbrain barrier penetrationbrain attackbrain blood circulationbrain blood flowcardiac infarctcase reportcerebralcerebral blood flowcerebral circulationcerebral vascularcerebral vascular accidentcerebro-vascularcerebrocirculationcerebrovascularcerebrovascular accidentcerebrovascular blood flowcerebrovascular imagingclinical developmentco-morbidco-morbiditycomorbiditycoronary attackcoronary infarctcoronary infarctiondiabetesdiabeticdrug/agentexperimentexperimental researchexperimental studyexperimentshandsheart attackheart infarctheart infarctionhigh blood pressurehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderin vivoinfarctknockin micelight scatteringmAbsmalemigraine therapymigraine treatmentmini strokemini-strokemonoclonal Absmortalitynoveloptic imagingoptical Doppler tomographyoptical coherence Doppler tomographyoptical imagingoptogeneticspathophysiologypatient populationpreclinical findingspreclinical informationresponserisk mitigationsmall moleculespreading depressionstrokedstrokestwo photon excitation microscopytwo photon microscopyvascularvascular risk factor♀♂
Description preview
Small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (“gepants”) and anti-CGRP or anti-
CGRP-receptor monoclonal antibodies (“nezumabs”) are novel treatments for migraine. However, endogenous
CGRP is among the most potent vasodilator molecules, and CGRP-mediated vasodilation is a critical rescue
mechanism in cerebral…
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