grant
Saccharomyces cerevisiae microtubule and kinetochore dynamics
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 1 Jun 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ATP-protein phosphotransferaseAnaphaseArtifactsAssayBaker's YeastBehaviorBindingBioassayBiochemicalBiological AssayBirthBirth DefectsBrewer's YeastBudding YeastCancersCell BodyCell CycleCell Cycle StageCell Division CycleCell NucleusCellsCellular MatrixChromosomesComplexCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCouplingCytoplasmCytoskeletal SystemCytoskeletonDNADefectDeoxyribonucleic AcidDevicesEndomycetalesFluorescence Light MicroscopyFluorescence MicroscopyGeneticGrowing End of the MicrotubuleKinase Family GeneKinesinKinetochoresLaboratoriesLateralM PhaseMalignant NeoplasmsMalignant TumorMediatingMicro-tubuleMicrotubulesMitosisMitosis StageMitoticMitotic AnaphaseMitotic spindleMolecular InteractionMolecular MachinesMorphologic artifactsNucleusParturitionPlus End of the MicrotubuleProcessPropertyProtein DynamicsProtein KinaseProteinsRegulationS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSaccharomycetalesSourceStructureSystemTimeTubulincancer preventionchromosome replicationdaughter cellgenome integritygenomic integrityglycogen synthase a kinasehydroxyalkyl protein kinaseintracellular skeletonmalignancymutantneoplasm/cancerphosphorylase b kinase kinasepreservationprotein complexsegregation
Description preview
Project Summary/Abstract
For replicated chromosomes to be segregated to two daughter cells accurately, the microtubule (MT)
cytoskeleton must be completely remodeled to form a bipolar spindle. A large, dynamic protein complex called
the kinetochore attaches replicated chromosomes to microtubules emanating from opposite spindle poles.
Proper…
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