grant
Rosettes in Adrenal Development, Maintenance and Disease
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 19 Sept 2019Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025ActomyosinAdherens JunctionAdhering JunctionAdhesive JunctionAdrenal CortexAdrenal FasciculataAdrenal GlandsAdrenal GlomerulosaAdrenalsAffectAldosteroneAldosteronismAllelesAllelomorphsAnchoring JunctionAngIIAngiotensin IIAtomic Force MicroscopyAutoregulationBFR-1Beta Cadherin-Associated ProteinBeta-1 CateninCAP102 proteinCUL-2Cell BodyCell Communication and SignalingCell SignalingCellsComplexCuesDNA Synthesis FactorDataData SetDevelopmentDiseaseDisorderEndocrine HypertensionEndothelial Cell Growth FactorEventFGFFGF ReceptorsFGF-RFGFRFGFR2FGFR2 geneFRETFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Factor Receptor 2 GeneFibroblast Growth Factor Receptor FamilyFibroblast Growth Factor ReceptorsFibroblast Growth Regulatory FactorFluorescence Resonance Energy TransferForce MicroscopyFunctional RNAFutureFörster Resonance Energy TransferGWA studyGWASGenesHeterozygoteHigh PrevalenceHomeostasisHomolog of Xenopus XWNT2HumanHyperaldosteronismHyperplasiaHyperplasticHypertensionHypoaldosteronismImmunoblottingIn VitroIntracellular Communication and SignalingKGFR GeneKSAM-1Keratinocyte Growth Factor Receptor GeneLigandsLineage TracingMaintenanceMediatingMediatorMetabolicMiceMice MammalsModelingModern ManMolecularMorphogenesisMurineMusNoncoding RNANontranslated RNAPRO2286Pathway interactionsPatientsPersonsPhysiologicPhysiologicalPhysiological HomeostasisProcessProductionProteomicsReceptor ProteinRecombinantsRegulationReporterResolutionRiskRisk-associated variantRoleScanning Force MicroscopySignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceStructureTK14TestingUntranslated RNAUpregulationVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderWNT13WNT2BWNT2B geneWestern BlottingWestern ImmunoblottingWingless-Type MMTV Integration Site Family, Member 13Wingless-Type MMTV Integration Site Family, Member 2BZona FasciculataZona Glomerulosaadrenal gland cortexadrenal hypertensionalpha E-cateninalpha cateninalpha-1 cateninalphaE cateninbeta catbeta cateninbiological signal transductionblebbistatincadherin-associated protein 102 kDacell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingdevelopmentalgain of functiongain of function mutationgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyheterozygosityhigh blood pressurehigh riskhyperpiesiahyperpiesishypertensive diseasehypertensive disorderin vivoinhibitorinsightloss of functionmorphogenetic processmouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynoncodingnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathwaypharmacologicpost-natal developmentpostnatalpostnatal developmentprotein blottingreceptorresolutionsresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsocial rolesuprarenal glandtherapeutic targettranscriptomicstransdifferentiationwhole genome association analysiswhole genome association studyα-cateninαE-cateninβ-catenin
Description preview
The adrenal cortex continuously remodels in response to physiological cues, though the precise cellular and
molecular mechanisms remain poorly understood. Our prior studies show that the adrenal cortex undergoes
zonal transdifferentiation during postnatal development in the zona Glomerulosa (zG) gives rise to the zona
Fasciculata (zF). This…
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