grant
Roles of parvalbumin-expressing neurons in primate cortical processing
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 16 Mar 2025Deadline 15 Mar 2028
NIHUS FederalResearch GrantFY2025Adeno-Associated VirusesAttentionBrainBrain Nervous SystemCalcium-Binding ProteinsCell BodyCellsColorCommunicationContrast SensitivityDNA TherapyData AnalysesData AnalysisDependoparvovirusDependovirusDevelopmentDiseaseDisorderDysfunctionEducational process of instructingEncephalonEngineeringEnhancersFacultyFoundationsFrequenciesFunctional disorderFutureGene Transfer ClinicalGeneticGenetic InterventionHumanLaser ElectromagneticLaser RadiationLasersMacacaMacaqueMeasuresMediatingMental disordersMental health disordersMentorshipMethodsMiceMice MammalsModelingModern ManMurineMusNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronal DysfunctionNeuronsOpsinOpticsParvalbuminsPhysiologyPhysiopathologyPrimary visual cortexPrimatesPrimates MammalsProcessPropertyPsychiatric DiseasePsychiatric DisorderRepressionResearchResearch ResourcesResourcesRod-OpsinRoleSensory ProcessStimulusStriate CortexStriate areaSupervisionTeachingTechniquesTestingTrainingUniversitiesV1 neuronViral GeneticsVisual Contrast SensitivityVisual SystemWashingtonWidthWorkadeno associated virus grouparea striatacell typecomparativecomputer based predictiondata interpretationdensitydevelopmentalexcitatory neuronexperienceexperimentexperimental researchexperimental studyexperimentsgene repair therapygene therapygene-based therapygenetic therapygenomic therapyimprovedinhibitory neuronmembermental illnessmultisensoryneuralneural circuitneural circuitryneural dysfunctionneurocircuitryneurological diseaseneuronalneurophysiologicalneurophysiologyopticaloptogeneticsorientation preferenceorientation selectivitypathophysiologypredictive modelingpreferencepsychiatric illnesspsychological disorderresponsesensory integrationsocial rolesynaptic circuitsynaptic circuitrytoolvirus genetics
Description preview
PROJECT SUMMARY/ABSTRACT
Inhibitory neurons likely underlie many neural computations. They are highly conserved in neural circuits
throughout the brain and their dysfunction has been implicated in many neurological and psychiatric disorders.
But very little is known about how they contribute to neural computations, especially in the primate brain.…
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