grant
Roles of novel MRGPRX2/MrgprB2 signaling in mast cells on host defense and Inflammation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Dec 2019Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026ADRBK1ADRBK1 geneAcne RosaceaAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAgonistAllergicAllergic Contact DermatitisAllergic Eczematous DermatitisAnaphylactic ReactionAnaphylactic ShockAnaphylaxisAntibodiesAtopic DermatitisAtopic EczemaAtopic NeurodermatitisAttenuatedBARK1Beta-ARK-1BindingBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell Communication and SignalingCell DegranulationCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChargeChemotactic CytokinesChemotaxisChronicComplexCoupledCouplingCryo-electron MicroscopyCryoelectron MicroscopyCutaneous DisorderDNA mutationDefectDermatosesDevelopmentDiseaseDisorderDisseminated NeurodermatitisDrug AllergyDrug HypersensitivityElectron CryomicroscopyEngraftmentFDA licensed drugsFDA-approved agentsFDA-approved drugFDA-approved medicationsFDA-approved pharmaceuticalsFDA-approved therapeutic agentFamilyFood and Drug Administration approved drugFood and Drug Administration approved medicationsFood and Drug Administration approved pharmaceuticalsG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor Kinase FamilyG protein coupled receptor kinaseG-Protein-Coupled ReceptorsG-ProteinsGPCRGRKGRK2GTP-Binding ProteinsGTP-Regulatory ProteinsGenerationsGenetic ChangeGenetic defectGenetic mutationGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHLA-DR Associated Protein IIHivesHomologous Chemotactic CytokinesHost DefenseHumanHydrophobicityHypersensitivityIGAADIgEImmuneImmunesImmunoglobulin EIn VitroInflammationInflammatoryInhibitor of GZMA-Activated DNaseIntercrinesIntracellular Communication and SignalingKI miceKinasesKnock-in MouseMarrowMarrow Mast CellMast-Cell DiseaseMediatingMembraneMiceMice MammalsModern ManMolecular InteractionMurineMusMutationNeurogenic InflammationPainPainfulPeptidesPhase 2 Clinical TrialsPhase II Clinical TrialsPhenotypePhosphatase 2A Inhibitor I2PP2APhosphorylationPhosphotransferase GenePhosphotransferasesProtein PhosphorylationPsoriasisReactionReceptor ProteinRegulationResearchRetroviridaeRetrovirusesRoleRosaceaSET Translocation Inhibitor-2 of Protein Phosphatase-2ASIS cytokinesSet proteinSignal TransductionSignal Transduction SystemsSignalingSkin DiseasesSkin Diseases and ManifestationsSpecificityStem Cell ResearchStructureSubcellular ProcessTM DomainTemplate Activating Factor I BetaTestingTissue BasophilsTissuesToxic effectToxicitiesTransmembrane DomainTransmembrane RegionTransphosphorylasesUrticariaVariantVariationVirus-Retrovirusadapter proteinallergic dermatitisallergic eczemaarrestin Battenuateattenuatesattenuationbeta-arrestinbiological signal transductionchemoattractant cytokinechemokinecryo-EMcryoEMcryogenic electron microscopycutaneous diseasecytokinedermal diseasedermal disorderdesensitizationdevelopmentaldisease phenotypegenome mutationin vitro activityin vivoinflammatory modulationinhibitorinterestknock-downknockdownknockin micemast cellmast cell hyperplasiamastocytemastocytosismembrane structuremutantnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachphase II protocolprotein activationpsoriasiformpsoriaticreceptorreceptor functionrecruitresponseskin disordersmall molecular inhibitorsmall molecule inhibitorsocial rolestem cell studyβ-arrestin
Description preview
Summary:
Mast cells (MCs) are tissue-resident immune cells that are best known for mediating IgE/FcεRI-mediated
hypersensitivity and atopic disorders. However, recent excitement in MC research has been the realization that
a diverse group of cationic amphipathic peptides and FDA-approved drugs activate human MCs via a novel G
protein coupled…
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