grant
Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Adult ProgeriaAgeAge of OnsetAttentionAutoregulationBindingBiochemicalBiologic ModelsBiologicalBiological FunctionBiological ModelsBiological ProcessCancersCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromosomal InstabilityChromosomal StabilityChromosome InstabilityChromosome SegregationChromosome StabilitiesComplexDNADNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA MaintenanceDNA RecombinationDNA RepairDNA ReplicationDNA StabilityDNA StructureDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA metabolismDNA mutationDNA replication forkDNA unwinding enzymeDeoxyribonucleic AcidDiagnosisDiseaseDisorderDysfunctionElementsEnzyme GeneEnzymesExonucleaseFEN-1FamilyFen1 ProteinFlap Endonuclease 1Functional disorderGene TranscriptionGenesGeneticGenetic ChangeGenetic ModelsGenetic RecombinationGenetic TranscriptionGenetic defectGenetic mutationGenome InstabilityGenome StabilityGenomic DNAGenomic InstabilityGenomic StabilityGoalsHomeostasisHumanHydrolysisKineticsMaintenanceMalignant NeoplasmsMalignant TumorMismatch RepairMitotic RecombinationModel SystemModern ManMolecularMolecular InteractionMolecular MotorsMutationNuclear ProteinsNucleic AcidsPathway interactionsPhysiological HomeostasisPhysiopathologyPlayPoikiloderma CongenitalePost-Replication Mismatch RepairPremature AgingPremature aging syndromePreventionPropertyProtein BiochemistryProtein/Amino Acid BiochemistryProteinsRAD2 Homolog-1 NucleaseRNA ExpressionRTH-1 NucleaseRecombinationRegulationRoleRothmund-Thomson syndromeSingle-Stranded DNAStructureSubcellular ProcessSystemTimeTranscriptionUnscheduled DNA SynthesisWRN ProteinWRN geneWerner SyndromeWerner Syndrome GeneWerner Syndrome ProteinWerner's syndromeWorkage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentagesbiologicbiological systemscancer predispositionchromosome divisiondisease phenotypegDNAgene productgenome integritygenome mutationgenomic integrityhelicasehuman DNAhuman diseasein vivointerestmalignancyneoplasm/cancernucleasenucleoside triphosphatepathophysiologypathwaypreferencepreservationpreventpreventingreplication forkresponsesocial rolessDNA
Description preview
Helicases are molecular motor proteins that couple the hydrolysis of nucleoside triphosphate to nucleic acid unwinding. Enzymes of this class function coordinately with other proteins as a complex machine and play essential roles in pathways of DNA metabolism that include replication, DNA repair, recombination, transcription, and chromosome…
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