grant
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Sept 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAdult-Onset Diabetes MellitusAffectAtrialBiopsyBlood SerumBody TissuesCancersCardiacCardiac AtriumCardiac Muscle CellsCardiac MyocytesCardiocyteCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell SignalingCessation of lifeChronicClinicalCoinCommunicationDataDeathDevelopmentDiagnosisDiastolic heart failureDiseaseDisorderDistalDysfunctionDyslipidemiasEatingEndocrineExhibitsFemaleFood IntakeFunctional disorderGene TargetingGenesGenetic PolymorphismGlucocorticoidsGluconeogenesisGlucose IntoleranceHF with preserved ejection fractionHFpEFHealthHeartHeart AtriumHeart HypertrophyHeart Muscle CellsHeart VascularHeart failureHeart myocyteHospital AdmissionHospitalizationHumanHypertensionImpairmentInflammatoryIntermediary MetabolismInterventionIntracellular Communication and SignalingJointsKetosis-Resistant Diabetes MellitusKinasesLeftLinkLiverLiver ExtractMacropainMacroxyproteinaseMalignant NeoplasmsMalignant TumorMaturity-Onset Diabetes MellitusMediatingMedicalMedicineMetabolicMetabolic MarkerMetabolic ProcessesMetabolic dysfunctionMetabolic syndromeMetabolismMiceMice MammalsModelingModern ManMolecularMorbidityMorbidity - disease rateMulticatalytic ProteinaseMurineMusNAFLDNIDDMNatureNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityObesity EpidemicObesity associated diseaseObesity related diseaseOrganOver weightOverweightPathogenesisPathologicPathologyPatientsPeptidesPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiopathologyPopulationPrevalenceProsomeProteasomeProteasome Endopeptidase ComplexProtein PhosphorylationProtein-Serine KinaseProtein-Serine-Threonine KinasesProtein-Threonine KinaseProteosomeRoleSGK1 proteinSerine KinaseSerine-Threonine KinasesSerine/Threonine Protein Kinase GeneSerumSerum-glucocorticoid-regulated kinase 1Sgk proteinSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusSyndromeSystemT2 DMT2DT2DMTestingTherapeuticThreonine KinaseTissuesTransphosphorylasesTreatment EfficacyType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVascular Hypertensive DiseaseVascular Hypertensive DisorderVentricularWeight GainWeight Increaseadipogenesisadiposityadult onset diabetesbiological signal transductionbody weight gainbody weight increasecardiac failurecardiac functioncardiac hypertrophycardiac metabolismcardiac preservationcardiometaboliccardiometabolismcardiomyocytecardiovascular disordercirculatory systemco-morbidco-morbiditycomorbiditycorpulencedesigndesigningdevelopmentaldiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdrug discoveryevidence baseflexibilityflexiblefunction of the heartglucose biosynthesisheart failure with preserved ejection fractionheart failure with preserved systolic functionheart functionheart metabolismheart preservationhepatic body systemhepatic organ systemhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimprovedinsulin signalinginterestintervention efficacyketosis resistant diabeteslipid biosynthesislipogenesismalemalignancymaturity onset diabetesmortalitymouse modelmulticatalytic endopeptidase complexmurine modelneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobese individualsobese peopleobese personobese populationobese subjectsoverexpressoverexpressionpathophysiologyphospho-proteomicsphosphoproteomicspolymorphismpreserved ejection fraction heart failurepressureserum and glucocorticoid-regulated kinasesocial roletherapeutic efficacytherapy efficacytranscriptome profilingtranscriptomic profilingtype 2 DMtype II DMtype two diabeteswt gain♀♂
Description preview
Project Summary:
Heart failure with preserved ejection fraction (HFpEF) has emerged as the greatest unmet medical need in
cardiovascular medicine, comprising 50% of all HF cases, with a US prevalence of ³3 million. HFpEF is
associated with high morbidity and mortality, with a 5-year survival after hospitalization worse than most cancers
of ~35%…
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