grant
Roles for Mismatch Repair Proteins in Maintaining Genome Stability
NIHUS FederalResearch GrantFY2026AllelesAllelomorphsAneuploidAneuploidyAreaAssayBaker's YeastBioassayBiological AssayBrewer's YeastBuffersCancersCannot achieve a pregnancyChIP assayChromatinChromosomal RearrangementChromosome SegregationChromosomesClosure by LigationColon CancerColon CarcinomaComplexCrossing OverCruciform DNADNADNA RecombinationDNA ReplicationDNA Replication InductionDNA SequenceDNA SynthesisDNA biosynthesisDNA crossoverDNA mutationDataDefectDeoxyribonucleic AcidDifficulty conceivingDiseaseDisorderEnsureEnvironmentEukaryotaEukaryoteEventFailureFilamentFungal Drug ResistanceFungus drug resistantGametesGeneHomologGenetic ChangeGenetic Crossing OverGenetic RecombinationGenetic SuppressionGenetic defectGenetic mutationGenomeGenome StabilityGenomic StabilityGerm CellsGerm-Line CellsGestationHDACHDAC ProteinsHNPCC3HereditaryHistone DeacetylaseHolliday Junction DNAHolliday JunctionsHomologHomologous GeneHomologueHumanInfertilityInheritedIntermediate JunctionLigationMLH1MLH1 geneMalignant NeoplasmsMalignant TumorMapsMeasuresMeiosisMeiotic RecombinationMethodsMismatch RepairModelingModern ManMutL E Coli Homolog 1MutL E. Coli Homolog 1MutationPMS1PMS1 genePMSL1Partner in relationshipPathogenesisPlayPopulationPost-Replication Mismatch RepairPregnancyProcessProtein FamilyProteinsQuality ControlRecombinationReproductive CellsResearchResolutionRoleS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSex CellSister ChromatidSiteStressSyndromeTestingTherapeutic FungicidesWorkYeastsZonula Adherensanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantcancer in the colonchromatin immunoprecipitationchromosome divisioncohesioncostcrossover recombinationendonucleasefertility cessationfertility lossfitnessfungus drug resistancegene repairgenome integritygenome mutationgenome scalegenome-widegenomewidegenomic crossovergenomic integrityhPMS1homologous recombinationinfertileinitial cellinsightinter-homolog crossovermalignancymatemeioticmeiotic crossovermutantmutation scanningmutation screeningneoplasm/cancernon-sister chromatid exchangenonsister chromatid exchangeprematureprematuritypreventpreventingrepairrepair endonucleaserepair enzymerepairedresistance to anti-fungalresistant to anti-fungalresolutionssegregationsexual cellsocial role
Description preview
Mismatch repair (MMR) factors, which act to remove DNA replication misincorporation errors, also function in
genetic recombination and in adaptation to stress. The latter two roles are the current focus of my research
efforts. Research Area 1 is centered on crossing over, a process critical in most eukaryotes for the accurate
segregation of…
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