grant
Roles for Intracellular pH Dynamics in Cancer
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jun 2016Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years old3-D3-Dimensional3DAddressAdultAdult HumanAffinityBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBiophysicsBiopsyBiosensorBody TissuesCancersCell BodyCell membraneCellsCellular biologyChIP SequencingChIP-seqChIPseqChargeClinicalColorectal CancerColorectal NeoplasmsColorectal TumorsCytoplasmic MembraneDNADNA BindingDNA Binding DomainDNA Binding InteractionDNA boundDNA-Binding Protein MotifsDNA-Binding ProteinsDataDeoxyribonucleic AcidDisease ProgressionDissociationDrosophilaDrosophila genusEVI16Ecotropic Viral Integration Site 16ElectrostaticsEpitheliumEvolutionFOXC2FOXC2 geneFamilyFluorescence AnisotropyFundingGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticH-bondHeterogeneityHistidineHumanHydrogen BondingImmune SurveillanceImmunologic SurveillanceImmunosurveillanceIntratumoral heterogeneityInvadedLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLigand Binding ProteinLigand Binding Protein GeneLigandsMalignant CellMalignant NeoplasmsMalignant TumorMediatingMetabolicModern ManMolecularMolecular InteractionNormal CellNuclearNucleic AcidsNucleotidesOncogenesisOrganoidsOutcomePathway interactionsPhenotypePhosphatidesPhospholipidsPlasma MembranePopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProgenitor CellsPropertyProtein BindingProtein ModificationProteinsRecombinant DNARecombinant DNA Molecular BiologyReporterReportingRoleSOX4SOX4 geneSRY-Box 4SRY-Related HMG-Box Gene 4Somatic MutationSpecificityTestingTherapeuticTimeTissuesTitrationsTranscription Factor Proto-OncogeneTranscription factor genesTumor CellTumor Suppressor ProteinsWorkadulthoodanti-cancer researchbiological sensorbiophysical foundationbiophysical principlesbiophysical sciencesbound proteincancer cellcancer cell metabolismcancer metabolismcancer progressioncancer researchcell behaviorcell biologycellular behaviorchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcolon cancer patientscolorectal cancer patientscolorectal neoplasiadeprotonationdesigndesigningfruit flygenome scalegenome-widegenomewideheterogeneity in tumorsimaging in vivoin vivoin vivo imaginginsightintra-tumoral heterogeneityintratumor heterogeneitylarge bowel neoplasmlongitudinal imagingmalignancymouse modelmurine modelneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayplasmalemmapreferenceprogenitor cell differentiationprogenitor differentiationprognostic abilityprognostic powerprognostic utilityprognostic valueprotonationscRNA sequencingscRNA-seqserial imagingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesomatic variantspheroidsstem and progenitor differentiationstem cell differentiationstem cellsthree dimensionaltranscription factortranscriptomicstumortumor cell metabolismtumor heterogeneitytumor metabolismtumor progressiontumor suppressortumorigenesis
Description preview
Abstract
Although cancers have a constitutively increased intracellular pH (pHi) that enables disease progression, the
molecular mechanisms mediating pHi-dependent cancer cell behaviors are understudied and incompletely
understood. During the funding period we bridged protein electrostatics and cell biology to identify molecular
mechanisms for pHi…
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