grant
Role of ZBP1 in pathogenesis of Salmonella biofilms
Organization RESEARCH INST OF FOX CHASE CAN CTRLocation PHILADELPHIA, UNITED STATESPosted 11 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AcuteAlimentary CanalAmyloidAmyloid SubstanceAnkylosing spondylitisAutoantibodiesAutoimmune StatusAutoimmunityAxial spondyloarthritisB Form DNAB-DNABacterial DNABacterial InfectionsBechterew DiseaseBindingCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCampylobacterCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCessation of lifeChronicClinicalComplexCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDNADeathDeoxyribonucleic AcidDigestive TractDiseaseDisorderDouble-Stranded DNAEpithelial CellsFibroblastsFiessinger Leroy Reiter syndromeGI TractGastrointestinal TractGastrointestinal tract structureGenerationsGenomic DNAHumanIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmunesIndividualIndustrializationInfectionInflammationInflammation MediatorsInflammatoryInterferon Type IInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Intracellular Communication and SignalingKinasesLeftLeft-Handed DNALigandsLong-term infectionMarie-Struempell DiseaseMediatingMiceMice MammalsMicrobial BiofilmsModern ManMolecular InteractionMorbidityMurineMusNatureNon-Polyadenylated RNANucleic AcidsOutcomePainPainfulPathogenesisPathway interactionsPatientsPhenotypePhosphotransferase GenePhosphotransferasesPositionPositioning AttributePost-Infectious ArthritisPostinfectious ArthritisPreventiveProcessProductionProtein SecretionProteinsRIP3RIPK3RIPK3 geneRNARNA Gene ProductsReactive ArthritisReceptor-Interacting Protein 3Receptor-Interacting Serine/Threonine Protein Kinase 3Reiter DiseaseReiter's syndromeReportingRheumatoid SpondylitisRibonucleic AcidRight-Handed DNARoleS entericaS enterica serovar TyphimuriumS typhimuriumS. entericaS. enterica TyphimuriumS. enterica serovar TyphimuriumS. typhimuriumSalmonellaSalmonella entericaSalmonella enterica TyphimuriumSalmonella enterica serovar TyphimuriumSalmonella infectionsSalmonella typhimuriumSalmonellosisShigellaSignal TransductionSignal Transduction SystemsSignalingSpondylarthritis AnkylopoieticaSymptomsTestingTherapeuticTherapeutically TargetableTransphosphorylasesViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirus DiseasesYersiniaZ-DNAZ-Form DNAacute infectionalimentary tractautoimmune antibodyautoreactive antibodybacteria infectionbacterial diseasebiofilmbiological signal transductioncell typechronic infectionchronic inflammatory diseasedigestive canalds-DNAdsDNAenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteropathogenenteropathogen infectionenteropathogenic infectiongDNAgastrointestinal symptomimmunogenicinfected with enteropathogeninflamed jointinflammatory mediatorinhibitorintestinal epitheliumintestinal infectionintestinal pathogenintestine infectionintestine pathogenjoint inflammationjoint swellingkinase inhibitormodel organismmortalitymouse modelmurine modelmutantnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypersistent infectionpreventpreventingrepurposingresponseself reactive antibodysensorsmall moleculesocial rolesystemic inflammationsystemic inflammatory responseviral infectionvirus infectionvirus proteinvirus-induced diseasezDNA
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PROJECT SUMMARY
Infections with enteric pathogens such as Salmonella, Campylobacter, Shigella, or Yersinia are leading causes
of morbidity and mortality worldwide. Although in most individuals the infection resolves, approximately 5% of
patients subsequently develop a painful chronic inflammatory condition known as Reactive Arthritis (ReA). How…
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