grant
Role of tissue differentiation factors in endocrine tumorigenesis
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ATRXATRX geneAdenohypophysisAdrenal Gland NeoplasmsAdrenal Gland TumorAdrenal TumorAffectAngiofibromaAngiofibromatous HyperplasiaAnterior Pituitary GlandAnterior pituitaryApoptosisApoptosis PathwayApoptoticB9 endocrine pancreasBING2Basal Transcription FactorBasal transcription factor genesBenign and Malignant Esophageal NeoplasmsBeta CellBeta Cell NeoplasmBeta Cell Neoplasm of the PancreasBeta Cell Tumor of the PancreasBinding ProteinsBiologicalBiological MarkersBloodBlood Precursor CellBlood Reticuloendothelial SystemBody TissuesCBLBCBLB geneCNS TumorCNS neoplasmCarcinoidCarcinoid NeoplasmCarcinoid Neoplasm of the ThymusCarcinoid TumorCell BodyCell Cycle ProgressionCell DifferentiationCell Differentiation processCell Growth in NumberCell LineCell MultiplicationCell NucleusCell ProliferationCellLineCellsCellular ProliferationCentral Nervous System NeoplasmsCentral Nervous System TumorsChIP SequencingChIP-seqChIPseqCollagen HamartomaCollagen NevusCollagen nevus of skinCollagenomaConnective Tissue NevusDAXXDAXX geneDNA mutationDataDeath Associated Protein 6DefectDiabetes MellitusDiabetes mellitus syndrome in newborn infantDisease of parathyroid glandsES cellEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndocrineEndocrine Gland NeoplasmsEndocrine PancreasEndocrine System NeoplasmEndocrine System TumorEndocrine TumorEpendymomaEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEsophageal NeoplasiaEsophageal NeoplasmsEsophageal TumorEsophagus NeoplasmEsophagus TumorEventExpression SignatureFaceFatty TumorFibroid UterusFibrous PapuleForegutGSK-3betaGSK-3beta inhibitorGSK-3βGSK-3β inhibitorGSK3b inhibitorGSK3β inhibitorGene AlterationGene ExpressionGene Expression ProfileGene MutationGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGerm-Line MutationGoalsHematopoietic Progenitor CellsHematopoietic stem cellsHereditaryHereditary MutationHeterozygoteHumanImpairmentInheritedInsulin CellInsulin Secreting CellInsulin-Producing Neoplasm of the Islet CellsInsulin-Producing Tumor of the Islet CellsInsulomaIntestinal Neuroendocrine NeoplasmIntestinal Neuroendocrine TumorInvestigationIsland Cell TumorIslands of LangerhansIslet Cell NeoplasmIslet Cell TumorIslets of LangerhansIsoformsJuvenile AngiofibromaKinasesLeiomyomaLigand Binding ProteinLigand Binding Protein GeneLinkLipomaLithium ChlorideMEA Type 1MEA Type IMEAIMEN Type 1MEN Type IMEN1 geneMediatingMeninMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModern ManMolecularMolecular FingerprintingMolecular ProfilingMultiple Endocrine Adenomatosis Type 1Multiple Endocrine Neoplasia 1Multiple Endocrine Neoplasia Type 1Multiple Endocrine Neoplasia Type IMultiple Endocrine Type 1 NeoplasmsMultiple Endocrine Type I NeoplasmsMurineMusMutationNatureNeoplasm MetastasisNesidioblastsNeuroendocrine CellNeuroendocrine NeoplasmNeuroendocrine TumorsNuclear RNANucleusOncogenesisOncogenicPanNetsPancreasPancreas NeoplasmsPancreas TumorPancreaticPancreatic Beta Cell Insulin Producing NeoplasmPancreatic Beta Cell Insulin Producing TumorPancreatic Beta Cell TumorPancreatic Endocrine NeoplasmPancreatic Endocrine TumorPancreatic IsletsPancreatic Neuroendocrine TumorPancreatic TumorParathyroidParathyroid AdenomaParathyroid DiseasesParathyroid Gland AdenomaParathyroid Gland DisorderParathyroid Gland NeoplasmParathyroid Gland TumorParathyroid Head and NeckParathyroid NeoplasmsParathyroid TumorParathyroid glandPars Anterior Pituitary GlandPars endocrina pancreatisPathogenesisPathway interactionsPatientsPhosphorylationPhosphotransferase GenePhosphotransferasesPolyamine CompoundPolyaminesPrimitive foregut structureProgrammed Cell DeathProtein BindingProtein IsoformsProtein PhosphorylationProteinsProto-Oncogene Protein c-metRNA SeqRNA sequencingRNA-Binding ProteinsRNAseqReceptor ProteinRecurrenceRecurrentRegulationRoleScatter Factor ReceptorSecondary NeoplasmSecondary TumorSmall IntestinesSmooth Muscle NeoplasmSmooth Muscle TumorSpecific qualifier valueSpecificitySpecifiedStomachStrains Cell LinesSyndromeTelangiectatic FibromaTherapeuticThymic CarcinoidThymic Carcinoid NeoplasmThymic Carcinoid TumorThymic NeoplasmsThymic TumorsThymomaThymusThymus CarcinoidThymus Carcinoid TumorThymus GlandThymus NeoplasmsThymus ProperThymus Reticuloendothelial SystemThymus TumorsTissue DifferentiationTissuesToxinTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTumor CellType I Multiple Endocrine AdenomatosisUpregulationUremiaUterine Body FibroidUterine Body LeiomyomaUterine Corpus FibroidUterine Corpus LeiomyomaUterine FibroidsUterine FibromaUterine LeiomyomaUterus FibromaWHO Grade II Ependymal NeoplasmWHO Grade II Ependymal TumorWell-Differentiated Endocrine NeoplasmWermer Syndromeadrenal neoplasmalpha thalassemia mental retardation X-linked geneautosomebeta-Cell Adenomabeta-Cell Tumorbio-markersbiologicbiologic markerbiomarkerblood cell progenitorblood progenitorblood stem cellblood-forming stem cellbound proteinc-met Proteincancer metastasiscancer progressioncell transformationcell typecellular differentiationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical relevanceclinically relevantcorpus uteri fibroidcorpus uteri leiomyomacultured cell linecutaneous lesionsdermal lesiondesigndesigningdiabetesdifferentiation factorseffective therapyeffective treatmentembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellendocrine neoplasmepigeneticallyfacesfacialgastricgene defectgene expression patterngene expression signaturegenome mutationgerm-line defectgermline variantglycogen synthase kinase 3 betaglycogen synthase kinase 3 beta inhibitorglycogen synthase kinase 3βgsk-3 beta inhibitorhematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellheterozygosityinhibitorinhibitor druginhibitor therapeuticinhibitor therapyinsulinomainterestintestine neuroendocrine neoplasmintestine neuroendocrine tumorlater in lifelater lifelow-frequency mutationmeningiomamicrobialmolecular profilemolecular signaturemorphogenic factorsmorphogensmortalitymouse modelmurine modelmutantmutant alleleneonatal diabetesneonatal diabetes mellitusneoplasm progressionneoplastic cellneoplastic progressionneuroendocrine differentiationp190 (MET)pancreatic NETpancreatic islet neoplasmpancreatic neoplasiapancreatic neoplasmparathyroid disorderpathwaypituitary anterior lobepituitary gland anterior lobeposttranscriptionalprotein expressionproteomic signaturerare allelerare mutationrare variantreceptorresistance mechanismresistant mechanismskin lesionsmall bowelsocial rolestem cell of embryonic originsynthetic peptidetelomeretherapeutic targettranscription factortranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomicstransformed cellstumortumor cell metastasistumor of the central nervous systemtumor progressiontumorigenesistumors in the central nervous systemuremia of renal originuterus leiomyomaα-thalassemia mental retardation X-linked geneβ-cellβ-cellsβCell
Description preview
Germline mutations in the MEN1 gene encoding menin predispose to endocrine tumors mainly of the parathyroids, anterior pituitary and entero-pancreatic endocrine tissues. Other endocrine tumors observed in MEN1 patients include nonfunctioning adrenal tumors, nonfunctioning foregut carcinoids - gastric neuroendocrine tumor (NET), thymic NET, and…
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