grant
Role of the SFTA2/ADGRF5 signaling axis in alveolar homeostasis
Organization NATIONAL JEWISH HEALTHLocation DENVER, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldARDSAcidsAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAffinityAlveolarAssayAttenuatedAutoregulationBindingBioassayBiological AssayBody TissuesBreathingCell BodyCell Communication and SignalingCell SignalingCellsChildChild YouthChildren (0-21)Chromosome 6Clinical TrialsCoupledDa Nang LungDataDiffuseDiseaseDisorderDistalDoseDysfunctionEpistasisEpistatic DeviationEpithelial CellsEpitheliumExternal DomainExtracellular DomainFormulationFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGasesGenesGeneticGenetic DiseasesGenetic EpistasisGenetic ModelsGoalsHomeostasisHumanIdiopathic respiratory distressImpairmentInflammationInjuryInteraction DeviationIntracellular Communication and SignalingKnowledgeLigandsLinkLungLung Alveolar EpitheliaLung DiseasesLung Respiratory SystemLung SurfactantMediatingMetabolic GlycosylationMiceMice MammalsModern ManMolecularMolecular InteractionMolecular TargetMurineMusNRDSNeonatal Acute Respiratory Distress SyndromeNeonatal Respiratory DistressNewborn RDSOrphanPathway interactionsPatientsPhenocopyPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPneumoniaPre-Clinical ModelPreclinical ModelsProtein GlycosylationProtein SecretionProteinsPulmonary Alveolar ProteinosisPulmonary DiseasesPulmonary DisorderPulmonary SurfactantsReceptor ProteinRespiratory AspirationRespiratory Distress in NeonatesRespiratory InspirationRiskRodentRodentiaRodents MammalsRoleShock LungSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStiff lungStructureSurfactant therapyTestingTherapeuticTissuesType II PneumocyteVentilatorWorkadulthoodalveolar epitheliumalveolar homeostasisalveolar type II cellattenuateattenuatesbiological signal transductiondisease of the lungdisorder of the lungepistatic interactionepistatic relationshipgain of functiongene x gene interactiongenetic conditiongenetic disordergenetic epistasesglycosylationin vivoinjuriesinsightinspirationkidsloss of functionlung disorderlung functionmouse geneticsmouse modelmurine modelneonatal RDSneonatal respiratory distress syndromeneonatal surfactant deficiencynewborn idiopathic respiratory distressnewborn pulmonary hypoperfusion syndromenewborn respiratory distressnewborn respiratory distress syndromenoveloverexpressoverexpressionpathophysiologypathwaypharmacologicpre-clinicalpreclinicalpreventpreventingpulmonarypulmonary functionreceptorrespiratory distress at birthsocial rolesurfactantsurfactant functiontherapeutic surfactantstherapeutic targettraffickinguptakewet lungyoungster
Description preview
PROJECT SUMMARY
Pulmonary alveolar homeostasis is dependent upon balanced airway and tissue surfactant pools. Alterations in
alveolar surfactant pools are associated with inflammation and tissue destruction in severe lung diseases
including acute respiratory distress syndrome, pulmonary alveolar proteinosis and genetic disorders of surfactant…
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