grant
Role of the Retrosplenial Cortex in the Progression of AD Pathogenesis in Mouse and Human
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202565 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD modelAD pathologyAcuteAdverse ExperienceAdverse eventAffectAged 65 and OverAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease therapeuticAlzheimer's pathologyAlzheimer's patientAlzheimer's therapeuticAlzheimers DementiaAmericanAmmon HornAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid depositionAmyloid βAmyloid β-PeptideAmyloid β-ProteinAreaAutomobile DrivingAutopsyAβBehaviorBehavioralBiologicalBrainBrain Nervous SystemBrain regionCaringCell BodyCellsCodeCoding SystemCornu AmmonisDREADDsDataDepositDepositionDevelopmentDiseaseDisease ProgressionDisorderDrug TargetingDysfunctionElementsEncephalonEventExhibitsFoundationsFunctional disorderFutureGene ExpressionGene TranscriptionGenesGenetic TranscriptionGliaGlial CellsGyrus CinguliHippocampusHumanHyperactivityImmune mediated therapyImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyImpairmentIn SituIntermediary MetabolismInterventionKolliker's reticulumLiteratureLocalized DiseaseMT-bound tauMapsMeasurementMembrane PotentialsMemory DeficitMemory LossMemory impairmentMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModelingModern ManModificationMolecularMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellOntologyPathogenesisPathologicPathway interactionsPatientsPersonsPhasePhenotypePhysiologicPhysiologicalPhysiopathologyPlayPositionPositioning AttributePrimary Senile Degenerative DementiaPropertyProteinsProteomicsRNA ExpressionResistanceRestResting PotentialsRodentRodent ModelRodentiaRodents MammalsRoleSamplingSingle-Nucleus SequencingSliceSynapsesSynapticTauopathiesTestingTimeTranscriptionTransmembrane PotentialsValidationa beta peptideabetaabeta depositionabove age 65after age 65age 65 and greaterage 65 and olderage 65 or olderageage associatedage correlatedage dependentage linkedage of 65 years onwardage relatedage specificaged 65 and greateraged 65+aged ≥65alzheimer modelamyloid betaamyloid beta depositionamyloid β depositionamyloid-b proteinaβ depositionbeta amyloid fibrilbiologicbrain tissuecell cortexcell typecingulate cortexcingulate gyrusdesigner receptors exclusively activated by designer drugsdevelopmentaldifferential expressiondifferentially expresseddrivingexcitotoxicexcitotoxicityexperimentexperimental researchexperimental studyexperimentsgene conservationhigh dimensionalityhippocampalhuman old age (65+)human tissuehyper-phosphorylated tauhyperphosphorylated tauimmune drugsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentmemory declinememory dysfunctionmemory recallmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmouse modelmurine modelnecropsynerve cementneural circuitneural circuitryneurocircuitryneurofibrillary tangle formationneuronalneuropathologic tauneuropathological taunew approachesnovel approachesnovel strategiesnovel strategyover 65 yearspatch clamppathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepostmortempostsynapticpre-clinicalpreclinicalpreservationpreventpreventingprimary degenerative dementiaresistantsNuc-Seqsenile dementia of the Alzheimer typeside effectsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesoluble amyloid precursor proteinspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial memoryspatial navigationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynapsesynapse functionsynaptic circuitsynaptic circuitrysynaptic functiontangle formationtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytherapeutic agent developmenttherapeutic candidatetherapeutic developmenttherapeutic outcometherapy outcometranscriptional differencestranscriptomicsvalidationsway findingwayfindingτ Proteins≥65 years
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PROJECT SUMMARY
While recent immunotherapies for Alzheimer’s disease (AD) have shown promise, they come with significant
side effects and may not work equally well for patients at different stages of AD. This necessitates a continued
focus on the development of AD therapeutics, especially on identifying the earliest drivers of AD. First, it is…
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