grant
Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 10 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoVAcuteAffectAnimal ModelAnimal Models and Related StudiesAnti-viral AgentsBioinformaticsBioinformatics coreBioinformatics research coreBioinformatics resource coreBiologicalBiological MarkersBiometricsBiometryBiostatisticsBiostatistics CoreBloodBlood - brain barrier anatomyBlood CirculationBlood Coagulation DisordersBlood Reticuloendothelial SystemBlood SampleBlood specimenBlood-Brain BarrierBloodstreamBody TissuesBrainBrain Nervous SystemBrain PathologyCASP11CASP4CASP4 geneCOVID disease severityCOVID infected patientCOVID patientCOVID positive patientCOVID severityCOVID-19COVID-19 disease severityCOVID-19 infected patientCOVID-19 infectionCOVID-19 patientCOVID-19 positive patientCOVID-19 severityCOVID-19 therapyCOVID-19 treatmentCOVID-19 virusCOVID-19 virus infectionCOVID19 disease severityCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 severityCOVID19 virusCV-19CardiacCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaspaseCaspase GeneCell BodyCell FunctionCell PhysiologyCell ProcessCell-Death ProteaseCellsCellular FunctionCellular PhysiologyCellular ProcessCellular injuryCerebrumCoV-2CoV2Coagulation DisorderCoagulopathyComplementComplement ProteinsCoronavirus Infectious Disease 2019Cysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDerivationDerivation procedureDevelopmentDiseaseDisorderDoseEC 2.1.1EncephalonEndothelial CellsEnzyme GeneEnzymesEventEvolutionGeneHomologGoalsHealthHeartHeart VascularHemato-Encephalic BarrierHistoryHomologHomologous GeneHomologueHumanICE and CED3 Homolog 2ICE-like proteaseICH-2ImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune responseImmunesImmunityImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionInfectionInflammasomeInflammationInflammatoryInflammatory ResponseInnate Immune ResponseKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLeadLong COVIDLong COVID-19Long coronavirus diseaseLong coronavirus disease 2019LungLung Respiratory SystemMaintenanceMediatingMethodsMethyltransferaseMiceMice MammalsModelingModern ManMouse Homolog of Caspase 11MurineMusNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersNon-Polyadenylated RNANull MouseOrganOutcomePathogenicityPathologyPatientsPb elementPopulationProductionPulmonary PathologyRNARNA Gene ProductsReactionReagentRecording of previous eventsReportingRespiratory DiseaseRespiratory System DiseaseRespiratory System DisorderRibonucleic AcidRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 disease severitySARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV-2 severitySARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2Severity of illnessSubcellular ProcessSymptomsSynaptic plasticitySyndromeTechniquesTestingTherapeuticThrombosisThrombusTissuesVaccinesVariantVariationViralViral BurdenViral DiseasesViral LoadViral Load resultVirus DiseasesVirus ReplicationWild Type MouseWuhan coronavirusadaptive immune responseanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbio-markersbiologicbiologic markerbiomarkerbleeding disorderbloodbrain barrierbrain circulationcell damagecell injurycell typecellular damagecellular targetingcerebralchronic COVIDchronic COVID-19chronic novel coronavirus disease 2019circulation of the braincirculatory systemclotting disordercollaborative approachcomplementationcoronavirus disease 2019coronavirus disease 2019 disease severitycoronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 severitycoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease severitycoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientcystein proteasecystein proteinasecysteine endopeptidasecytokinecytokine release syndromecytokine stormdamage to cellsdevelopmentaldisease severityemergent virusemerging virusexperienceexperimentexperimental researchexperimental studyexperimentsgene manipulationgenetic manipulationgenetically manipulategenetically perturbhCoV19heavy metal Pbheavy metal leadhistorieshost responseimmune cell-mediated thrombosisimmune system responseimmune-mediated thrombosisimmunoresponseimmunothrombosisimmunothromboticinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2infection with SARS-CoV-2injury to cellsinsightlong haul COVIDlong haul COVID-19long haul coronavirus diseaselong haul coronavirus disease 2019long-hauler COVIDlong-hauler COVID-19long-hauler coronavirus disease 2019long-hauler syndromelong-term COVIDlong-term COVID-19long-term coronavirus diseaselong-term coronavirus disease 2019long-term sequelaelung pathologymembermethylasemodel of animalmyelinationnCoV2nano particlenano-sized particlenanoparticlenanosized particleneural inflammationneuroinflammationneuroinflammatoryneurological diseasenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon vaccinatednot vaccinatednovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2persistent COVID-19post COVID syndromepost COVID-19 syndromepost acute COVID syndromepost acute COVID-19post acute COVID-19 syndromepost acute SARS-CoV-2post acute coronavirus disease 2019post acute coronavirus disease 2019 syndromepost acute coronavirus disease syndromepost acute severe acute respiratory syndrome coronavirus 2post coronavirus disease 2019 syndromepost coronavirus disease syndromepost-acute phases of COVID-19preventpreventingprogramsprolonged COVID-19 symptomspulmonaryresponserestraintsevere acute respiratory syndrome coronavirus 2 disease severitysevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsevere acute respiratory syndrome coronavirus 2 severitysevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentshRNAshort hairpin RNAsmall hairpin RNAsocial rolesynergismtherapeutic targetthrombotic diseasethrombotic disordertraffickingtranscriptomicstranslational opportunitiestranslational potentialtransmethylasetreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2unvaccinatedviral emergenceviral infectionviral multiplicationviral reboundviral replicationviral resistancevirus infectionvirus multiplicationvirus reboundvirus resistancevirus-induced diseasewildtype mouse
Description preview
OVERALL - ABSTRACT
COVID-19 is a world-wide health problem caused by SARS-CoV-2 viral infection in the lung with
long-term symptoms in at least one third of patients. Many COVID-19 patients suffer from silent
or identified thrombi in major organs such as the lung and the brain and have increased
occurrence of cardiac events. They also experience…
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