grant
Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer's disease
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 May 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202525-hydroxycholesterolAD dementiaAD modelAD related dementiaADRDAPOEAPOE e3APOE e4APOE-ε4APOEε4AccelerationAcuteAffectAgeAgonistAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease modelAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmmon HornAmyloidAmyloid (Aβ) plaquesAmyloid PlaquesAmyloid SubstanceApo-EApoE proteinApolipoprotein EAstrocytesAstrocytusAstrogliaBrainBrain Nervous SystemCell BodyCellsCholesterolCholesterol EstersCholesterol HomeostasisCholesterol Synthesis InhibitionCholesteryl EstersCo-cultureCocultivationCocultureCoculture TechniquesCornu AmmonisDataDegenerative Neurologic DisordersDevelopmentDisease associated microgliaDysfunctionEncephalonEnzyme GeneEnzymesEsterificationFemaleFunctional disorderGene ExpressionGenesGenetic predisposing factorGenotypeGliaGlial CellsHippocampusHomolog of Drosophila TOLLHortega cellHydroxylasesImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionInflammatoryIsoformsKolliker's reticulumLate Onset Alzheimer DiseaseLipidsLipopolysaccharidesMT-bound tauMeasuresMediatingMediatorMiceMice MammalsMicrogliaMixed Function OxidasesMixed Function OxygenasesMonooxygenasesMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNon-neuronal cellNonneuronal cellPathogenesisPathogenicityPathologicPathway interactionsPhagocytesPhagocytic CellPhagocytosisPhysiopathologyPlayPrimary Senile Degenerative DementiaProductionProtein IsoformsReportingRoleSRE-2 binding proteinSREBP-2Senile PlaquesSingle-Nucleus SequencingStaining methodStainsSynapsesSynapticTLR4TLR4 geneTREM2TREM2 geneTauopathiesTestingToll HomologueTransgenic MiceTransgenic OrganismsTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2VariantVariationage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage related neurodegenerationage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderalzheimer modelalzheimer riskamebocyteamyloid beta plaqueamyloid-b plaqueanalyzing longitudinalapo E-3apo E-4apo E3apo E4apo epsilon4apoE epsilon 4apoE-3apoE-4apoE3apoE4apolipoprotein E epsilon 4apolipoprotein E-3apolipoprotein E-4apolipoprotein E3apolipoprotein E4astrocytic gliaaβ plaquesbrain tissuecell typecholest-5-ene-3 beta,25-diolcholesterol biosynthesischolesterol metabolismcored plaquecytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiffuse plaqueearly onsetfat metabolismgenetic risk factorgitter cellhippocampalinherited factorinhibitorlate onset alzheimerlateral ventriclelipid metabolismlipidomicslongitudinal analysismalemesogliamicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumouse modelmurine modelnerve cell deathnerve cell lossnerve cementneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroinflammationneuroinflammatoryneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuron toxicityneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal survivalneuronal toxicityneuropathologicneuropathologic tauneuropathologicalneuropathological tauneuropathologyneurotoxicitynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachosmotic minipumpoverexpressoverexpressionpathophysiologypathwayperivascular glial cellpiriform cortexpreventpreventingprimary degenerative dementiasNuc-Seqsenile dementia of the Alzheimer typesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesterol-regulatory element-binding protein 2synapsetangletautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytoll-like receptor 4transgenicτ Proteins♀♂
Description preview
PROJECT SUMMARY/ABSTRACT
Alzheimer disease (AD) is the most common neurodegenerative disorder characterized by neuroinflammation
associated with amyloid plaques and tau-containing neurofibrillary tangles in the brain as well as severe
neurodegeneration, neuroinflammation and lipid accumulation. The apolipoprotein E (APOE) genotype is by far
the…
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