grant
Role of the Environment, Mutographs and T Cell Immunity on MGUS
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingBiologicalBiologyBlack PopulationsBlack groupBlack individualBlack peopleBlacksBlood Plasma CellBone MarrowBone Marrow Reticuloendothelial SystemCancersCausalityCell FractionCensusesChromatin StructureClinicalDNA SequenceDNA mutationDataDiseaseDisorderEarly DiagnosisEconomic IncomeEconomical IncomeEducationEducational aspectsEmploymentEnvironmentEnvironmental ExposureEtiologyEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFreezingFunctional RNAGenetic ChangeGenetic defectGenetic mutationGenomicsGoalsGroups at riskHealthHistoryHousingImmune responseImmunityImmunoglobulin V(D)J RearrangementIncomeIndividual AdjustmentInflammatoryInvestigationKnowledgeLengthMGUSMalignant NeoplasmsMalignant TumorMeasuresMediatingMemory B CellMemory B-LymphocyteModelingMonitorMonoclonal Gammopathy of Undetermined SignificanceMonoclonal Gammopathy of Unknown SignificanceMonoclonal gammopathy of uncertain significanceMultiple MyelomaMutationNoncoding RNANontranslated RNAPBMCParticipantPeople at riskPeripheral Blood Mononuclear CellPersons at riskPlasma CellsPlasma-Cell MyelomaPlasmacytesPopulationPopulations at RiskPrecancerous ConditionsPremalignant ConditionPremalignant StateRecording of previous eventsResearch ResourcesResourcesRiskRisk FactorsRoleSingle Base PolymorphismSingle Nucleotide PolymorphismSingle base substitutionStandardizationT cell responseT-CellsT-LymphocyteTestingTimeTransportationUntranslated RNAV(D)J RearrangementV(D)J RecombinationVDJ rearrangementVDJ recombinationVariantVariationVulnerable Populationsassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicbuilt environmentcase controlcase-controlledcausationcohesiondisease causationdisease riskdisorder riskdrivingearly detectionentire genomeexhaustionexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesflow cytophotometryfull genomegene signaturesgenetic signaturegenome mutationgenome sequencinghigh riskhistorieshost responseimmune system responseimmunoresponseimprovedincomesindelinnovateinnovationinnovativeinsertion/deletioninsertion/deletion mutationmalignancymalleable riskmarginalized groupmarginalized individualmarginalized peoplemarginalized populationmethods to study multiple-level influencesmodifiable riskmulti-level analysismulti-level modelmultilevel analysismultilevel modelmultilevel modelingmyelomamyelomatosisneo-antigenneo-epitopesneoantigensneoepitopesneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnoncodingnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpatient populationperipheral bloodplasmocyteprecancerous statereceptor expressionsingle nucleotide variantsocialsocial rolestructural mutationstructural variantstructural variationtherapeutically effectivethymus derived lymphocytetoolvulnerable groupvulnerable individualvulnerable peoplewhole genome
Description preview
ABSTRACT
The goal of this investigation is to characterize the influence of macro-level exposures on associations of mutational signatures and T-cell immunity in high-risk monoclonal gammopathy of undetermined significance (MGUS). MGUS is a necessary precursor to multiple myeloma (MM) suggesting that driver events accumulated at the early…
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