grant
Role of the brain-immune axis in neuropsychiatric disease
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202512-20 years old21+ years old22q11 Chromosomal Microdeletion Syndrome22q11 Deletion Syndrome22q11.2 deletion syndrome22q11.2DS22q11DSASDAbateAddressAdolescenceAdultAdult HumanAffectAmmon HornAutismAutistic DisorderAutomobile DrivingAutosomal dominant Opitz G/BBB syndromeB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BBB disruptionBBB functionBCDFBSF-2BSF2BehaviorBehavioralBeta Proprotein Interleukin 1Biological Response ModifiersBiomodulatorsBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemCNS Nervous SystemCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCayler cardiofacial syndromeCentral Nervous SystemCerebrovascular systemChildhoodChromosome 22q11.2 deletion syndromeClinicClinicalCommunicationCompetenceCornu AmmonisCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDevelopmentDi George syndromeDiGeorge SyndromeDiGeorge anomalyDiGeorge sequenceDiseaseDisorderDysfunctionEarly Infantile AutismEncephalonEnvironmentExhibitsFunctional disorderGenesGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic propensityGoalsHPGFHemato-Encephalic BarrierHepatocyte-Stimulating FactorHippocampusHumanHybridoma Growth FactorIFN-beta 2IFNB2IL-1 betaIL-1 βIL-1-bIL-17IL-17 GeneIL-17AIL-17A GeneIL-1βIL-6IL1-BetaIL1-βIL17IL17 ProteinIL17 geneIL17AIL17A GeneIL1B ProteinIL1F2IL1βIL6 ProteinImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune MediatorsImmune Mediators/ModulatorsImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune TargetingImmune mediated therapyImmune systemImmunesImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImmunotherapyImpairmentInfantile AutismInflammationInflammation MediatorsInflammatoryInflammatory ResponseInherited PredispositionInherited SusceptibilityInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin 1betaInterleukin-1 betaInterleukin-17Interleukin-1βInterleukin-6InterventionKanner's SyndromeLeadLinkLipopolysaccharidesMGI-2MediatingMemoryMental DepressionMental disordersMental health disordersMiceMice MammalsModelingModern ManMurineMusMyeloid Differentiation-Inducing ProteinNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuroimmuneNeuronsOntologyOutcomePathogenicityPatientsPb elementPeripheralPhenotypePhysiopathologyPlasmacytoma Growth FactorPredispositionPreinterleukin 1 BetaPreventative interventionPreventionProcessPropertyPsychiatric DiseasePsychiatric DisorderResearchRiskRoleSchizophreniaSchizophrenic DisordersScienceSedlackova syndromeShapesShprintzen syndromeStressSusceptibilitySymptomsT cell responseT-CellsT-LymphocyteTestingTherapeuticTranslatingWorkadolescence (12-20)adult youthadulthoodautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavior influencebehavior outcomebehavioral impairmentbehavioral influencebehavioral outcomeblood vessels in the brainblood-brain barrier disruptionblood-brain barrier functionbloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier functionbrain blood vesselsbrain vasculaturecerebral blood vesselcerebral vasculaturecerebrovascular vesselscerebrovasculatureclinical phenotypeclinical relevanceclinically relevantconotruncal anomaly face syndromecytokinedementia praecoxdepressiondevelopmentaldisease modeldisorder modeldrivingenvironmental stressesenvironmental stressorfamilial third and fourth pharyngeal pouch syndromegenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedheavy metal Pbheavy metal leadhippocampalhuman modelhypoimmunityimmune deficiencyimmune drugsimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunodeficiencyimmunologic therapeuticsimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapeuticsimmunotherapy agentimpaired behaviorimprovedinflammatory mediatorinsightinterferon beta 2intervention for preventionmental illnessmodel of humanmouse modelmurine modelneural inflammationneuro-vascularneuroinflammationneuroinflammatoryneuronalneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatric symptomneuropsychiatryneurovascularpathophysiologypediatricpharyngeal pouch syndromepreventpreventingprevention interventionpreventional intervention strategypreventive interventionpsychiatric illnesspsychological disorderresponseschizophrenicsmall moleculesocialsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolesymptomatologytherapeutic targetthird and fourth pharyngeal pouch syndromethymic and parathyroid agenesis syndromethymus derived lymphocyteundue influencevelo-cardio-facial syndromevelocardiofacial syndromevelofacial hypoplasiayoung adultyoung adult ageyoung adulthood
Description preview
The study of brain-immune interactions has contributed to a paradigm shift in the understanding of the
pathophysiology of mental disorders and has provided new insights into their prevention and treatment. Notably,
the blood-brain barrier (BBB) functions to restrict interactions between the brain and periphery, limiting the
influence of peripheral…
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