grant
Role of stromal inflammatory signaling in the aging of lung resident lymphocytes
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20254 HydroxyprolineAddressAgeAge FactorsAgingAlveolusAntibodiesAssayAutomobile DrivingAutoregulationBasal CellBioassayBiological AssayBiologyBody TissuesBronchial AlveolusCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCDK4ICDKN2CDKN2 GenesCDKN2ACDKN2A geneCMM2COPDCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell AgingCell BodyCell CommunicationCell Communication and SignalingCell CycleCell Cycle ArrestCell Division CycleCell InteractionCell SenescenceCell SignalingCell-to-Cell InteractionCellsCellular AgingCellular SenescenceCellular StressCellular Stress ResponseChemotactic CytokinesChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCirculationCo-cultureCocultivationCocultureCoculture TechniquesComplexCyclin-Dependent Kinase Inhibitor 2A GeneDasatinibDataDevelopmentDiseaseDisorderElderlyExhibitsExpression SignatureFibroblastsFibrosisGene Expression ProfileGene TranscriptionGenetic ModelsGenetic TranscriptionGoalsGrippeHealthHistologyHomeostasisHomologous Chemotactic CytokinesHydroxyprolineI Kappa B AI Kappa B-AlphaI kappa B-alpha proteinIKB-AlphaIKappaBIKappaB-AlphaIKappaB/MAD-3INK4INK4AIkappaBalphaImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImpairmentIn VitroIn vivo analysisInfectionInflammationInflammatoryInfluenzaIntercrinesIntracellular Communication and SignalingIκBαK-AwardsK-Series Research Career ProgramsKineticsLYT3LungLung DiseasesLung Respiratory SystemLung Tissue FibrosisLung infectionsLymphatic cellLymphocyteLymphocyticLymphoidMAD-3 proteinMAD3MAD3 inhibitorMTS1MTS1 GenesMajor Histocompatibility Complex Enhancer-Binding Protein MAD3MentorshipMesenchymalMesenchymasMesenchymeMiceMice MammalsMorbidityMorbidity - disease rateMurineMusNF-Kappa B Inhibitor AlphaNF-kappaB inhibitor alphaNamesNuclearNuclear Factor Kappa-B InhibitorNuclear Factor of Kappa Light Chain Gene Enhancer in B Cells InhibitorNuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, AlphaOxyprolinePD 1PD-1PD-1 antibodyPD1PD1 antibodyPathogenesisPathologicPhenotypePhysiciansPhysiological HomeostasisPlayPneumoniaPopulationProductionPulmonary DiseasesPulmonary DisorderPulmonary FibrosisQuercetinRNA ExpressionRNA SeqRNA sequencingRNAseqReplicative SenescenceReporterResearchResearch Career ProgramRoleSIS cytokinesScientistSignal InductionSignal TransductionSignal Transduction SystemsSignalingSourceT-CellsT-LymphocyteT8 CellsT8 LymphocytesTP16TSG9ATestingTissuesTrainingTranscriptionTransplantationUncertaintyUpregulationViralViral BurdenViral DiseasesViral LoadViral Load resultViral PneumoniaVirus DiseasesaPD-1aPD1adaptive immunityadvanced ageage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage reversalage specificage specific alterationsage specific changesagedaged miceaged mouseagesaging associatedaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging delayaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging relatedaging related alterationsaging related changesaging reversalaging specific alterationsaging specific changesalleviate age relatedalleviate agingalterations with ageameliorating aginganti programmed cell death 1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1attenuate agingbiological signal transductioncareercell stresschanges with agechemoattractant cytokinechemokinechronic obstructive pulmonary disorderconferenceconventioncounter age relatedcounter agingcounteract age relatedcounteract agingcytokinedecelerate agingdelay age relateddevelop therapydevelopmentaldifferential expressiondifferentially expresseddisease of the lungdisorder of the lungdoubtdrivingearly adulthoodelderly miceemerging adultepithelial progenitorepithelial progenitor cellepithelial stem cellexhaustionexperiencefibrosis in the lunggene expression patterngene expression signaturegeriatricimprovedin vitro testingin vivoin vivo evaluationin vivo testinginhibitorinjury to tissueintervention developmentknock-downknockdownlung disorderlung fibrosislung healthlung repairlung tissue repairlymph cellmortalitymouse modelmurine modelnamenamednamingneutralizing antibodynovelold micep14ARFp16 Genesp16INK4 Genesp16INK4A Genesp16INK4apause agingpostpone age relatedprogrammed cell death 1programmed cell death protein 1programmed death 1pulmonarypulmonary healthpulmonary infectionspulmonary repairrecruitreplicative agingretards agingreverse agereverse agingreverse aging effectsreversible agingscRNA sequencingscRNA-seqsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsenior citizensenolyticssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsle2slow agingslow down agingslow the rate of agingsocial rolesummitsymposiasymposiumsystemic lupus erythematosus susceptibility 2therapeutic targettherapy developmentthymus derived lymphocytetissue injurytissue repairtranscriptional differencestranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtransplanttreatment developmentviral infectionvirus infectionvirus-induced diseaseαPD-1αPD1
Description preview
PROJECT SUMMARY
Immune system dysfunction has been implicated in the pathogenesis of several age-related lung diseases.
Interestingly, multiple recent studies have identified the tissue microenvironment as playing a critical role in the
pathogenesis of some of these age-related immune system changes. The lung mesenchyme provides a
supportive niche…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click