grant
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitis
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years old7S Gamma GlobulinAcuteAdultAdult HumanAffectAngiitisAngiotensin II ReceptorAortic AneurysmAttenuatedAutomobile DrivingAwarenessBeta Proprotein Interleukin 1Blood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBlood monocyteBody TissuesCardiacCardiac DiseasesCardiac DisordersCardiac arteryCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCausalityCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell WallCell-to-Cell InteractionCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChildChild YouthChildhoodChildren (0-21)ClinicalContractile ProteinsCoronaryCoronary AneurysmCoronary arteryCoronary artery aneurysmDataDeathDendritic CellsDevelopmentDifferences between sexesDiffers between sexesDiseaseDisease ProgressionDisorderDysfunctionEtiologyExhibitsFemaleFeverFibroblastsFunctional disorderGene ExpressionHealthHeart DiseasesHeart VascularHeart arteryHumanIL-1IL-1 ReceptorsIL-1 betaIL-1 βIL-1-bIL-1βIL1IL1 ReceptorsIL1-BetaIL1-βIL1B ProteinIL1F2IL1βIgGIllness DaysImmuneImmunesImmunoglobulin GInfiltrationInflammationInflammatoryInterleukin 1betaInterleukin IInterleukin-1Interleukin-1 ReceptorsInterleukin-1 betaInterleukin-1βInterleukinsIntracellular Communication and SignalingIntravenousIschemic HeartIschemic Heart DiseaseIschemic myocardiumKawasaki DiseaseL caseiL. caseiLactobacillus caseiLeiomyocyteLesionLymphocyte-Stimulating HormoneMMPsMacrophageMacrophage Cell FactorMarrow NeutrophilMarrow monocyteMatrix MetalloproteinasesMediatingMedicalMiceMice MammalsModelingModern ManMucocutaneous Lymph Node SyndromeMurineMusMyocardial InfarctMyocardial InfarctionMyocardial IschemiaMyofibroblastMφNeutrophilic GranulocyteNeutrophilic LeukocyteOutcomePathogenesisPathologicPathologyPathway interactionsPatientsPhenotypePhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPreinterleukin 1 BetaPreventionProductionProliferatingPropertyPublishingPyrexiaRegulationResistanceRoleSeveritiesSex DifferencesSexual differencesSick DaySignal TransductionSignal Transduction SystemsSignalingSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellSourceStromal CellsSubcellular ProcessT Helper FactorTestingTherapeuticTissuesTranscriptVascular DiseasesVascular DisorderVascular Smooth MuscleVasculitisVeiled Cellsadulthoodattenuateattenuatesbiological signal transductionblood vessel disordercardiac infarctcardiac ischemiacardiovascular disordercausationcirculatory systemcomparing females and malescomparing women and mencoronary attackcoronary infarctcoronary infarctioncoronary ischemiadevelopmentaldisease causationdisparities in sexdrivingexperiencefebrilefebrisfemale patientsfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesheart attackheart disorderheart infarctheart infarctionheart ischemiahigh riskhuman diseaseimprovedkidslymphocyte activating factormalemonocytemouse modelmurine modelmyocardial ischemia/hypoxiamyocardium ischemianeutrophilnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwaypatients being femalepatients being womenpatients who are femalepediatricpreventpreventingrecruitresistantsexsex based differencessex dimorphismsex disparitysex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolestemtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptomicsvascularvascular dysfunctionvasculitidesvasculopathywomen compared to menwomen compared with menwomen patientswomen versus menwomen vs. menyoungster♀♂
Description preview
PROJECT ABSTRACT
Kawasaki disease (KD), an acute febrile illness and systemic vasculitis of unknown etiology, is the leading cause
of acquired heart disease among children in the US. Coronary artery aneurysms (CAA) develop in as many as
25% of untreated KD patients, resulting in ischemic heart disease, myocardial infarction, and even death.…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click