grant
Role of serum advanced glycation end-products in altering tendon properties with diabetes
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 25 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AGE receptorAddressAdult-Onset Diabetes MellitusAdvanced Glycation End ProductsAdvanced Glycosylation End ProductsAffectAmericanAutomobile DrivingAutoregulationBiomechanicsBlood GlucoseBlood SerumBlood SugarBovine Serum AlbuminCausalityCell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCell SurvivalCell ViabilityCell-Extracellular MatrixCellsChronicClinicalCollagenCollagen FiberCollagen FibrilComplications of Diabetes MellitusCritical PathsCritical PathwaysDataDecline in mobilityDecrease in mobilityDecreased mobilityDeteriorationDevelopmentDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDiabetic mouseDiminished mobilityECMEconomic BurdenEconomic ConditionsEconomical ConditionsEnvironmentEtiologyExtracellular MatrixExtracellular Matrix DegradationFoodFrequenciesGenesGeneticGlycohemoglobin AGlycosylated hemoglobin AGoalsHb A1Hb A1a+bHb A1cHbA1HbA1cHealthHemoglobin A(1)HomeostasisHumanHyperglycemiaImpairmentIndividualInflammationInjuryIntakeInterdisciplinary ResearchInterdisciplinary StudyIntracellular Communication and SignalingKetosis-Resistant Diabetes MellitusKidneyKidney Urinary SystemKnock-outKnockoutKnowledgeMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMaintenanceMaturity-Onset Diabetes MellitusMechanicsMediatingMediatorMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodologyMiceMice MammalsMissionMobility declineMobility impairmentModelingModern ManModificationModulusMorphologyMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusNIAMSNIDDKNIDDMNMR ImagingNMR TomographyNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNuclear Magnetic Resonance ImagingOxidative StressPathologyPatientsPersonsPhenotypePhysiological HomeostasisPlayPreventative strategyPrevention strategyPreventive strategyProcessPropertyQOLQuality of lifeRAGE receptorReceptor ActivationReduced mobilityReduction in mobilityResearchRiskRodentRodentiaRodents MammalsRoleSerumShapesSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSocietiesStable Diabetes MellitusStudy of serumT2 DMT2DT2DMTendon InjuriesTendon structureTendonsTestingTherapeuticType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkZeugmatographyadult onset diabetesadvanced glycation endproductadvanced glycosylation end product receptoradvanced glycosylation endproductamphoterin receptorbiological signal transductionbiomechanicalcausationcell culturecell culturescrosslinkdb/db mousedevelopmentaldiabetesdiabetes mouse modeldiabeticdimerdisease causationdrivingglycolaldehydehemoglobin A1chuman subjecthydroxyacetaldehydehyperglycemicimage-based methodimaging methodimaging modalityimprovedin vivoinhibitorinjuriesketosis resistant diabetesloss of functionmaturity onset diabetesmechanicmechanicalmouse modelmurine modelnew approachesnon-diabeticnondiabeticnovelnovel approachesnovel strategiesnovel strategypreventpreventingreceptor for AGEreceptor for advanced glycation end productreceptor for advanced glycation endproductsreceptor of AGErenalsocialsocial roletendon developmenttendon growthtendon maturationtreatment strategytype 2 DMtype II DMtype two diabetesultrasoundwestern dietwestern-style dietwestern-type diet
Description preview
PROJECT SUMMARY
Impaired tendon biomechanical function reduces mobility and quality of life for the majority of the ~30 million
Americans with diabetes, resulting in a substantial economic burden to these individuals and society. Any new
approach to enhancing tendon function in people with diabetes is hindered by a poor understanding of the…
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