grant
Role of Protein Interactions in Retina Development and Function
Organization NATIONAL EYE INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025(TNF)-α2 lysophosphatidylcholine acylhydrolaseAblationActive OxygenActive SitesAffinityAffinity ChromatographyAge related macular degenerationAge-Related MaculopathyAgingAmino Acid SubstitutionAmino AcidsAmmonium SulfateAmpullary CrestAngiogenesis AntagonistsAngiogenesis BlockersAngiogenesis InhibitorsAngiogenetic AntagonistsAngiogenetic InhibitorsAngiogenic AntagonistsAngiogenic InhibitorsAngiostatic AgentsAnimal ModelAnimal Models and Related StudiesAnti-Angiogenetic AgentsAnti-Angiogenic AgentsAnti-Angiogenic DrugsAntiangiogenesis AgentsAntiangiogenic AgentsAntiangiogenic DrugsAssayB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBODIPYBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBuffersC-terminalCRX proteinCachectinCalciumCell AgingCell Communication and SignalingCell DeathCell NucleusCell SenescenceCell SignalingCell SurvivalCell ViabilityCellular AgingCellular SenescenceCirculatory CollapseCollaborationsComplementary DNAComplexCone rod homeoboX proteinConfocal MicroscopyCorneal AngiogenesisCorneal NeovascularizationCrista ampullarisCrossbreedingDefectDetergentsDevelopmentE coliE. coliEC 3.1.1.4ELISAEPC-1 proteinElectronsEnzyme GeneEnzyme-Linked Immunosorbent AssayEnzymesEscherichia coliEster HydrolaseEsteroproteasesEvaluationExhibitsEyeEye DropsEyeballEyedropsFamilyFluorescenceFreezingFutureGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic HybridizationGenotypeHPGFHepatocyte-Stimulating FactorHereditaryHistologyHumanHybridoma Growth FactorHydrolaseHydrolase Family GeneHydrolase GeneHydrolysisIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNGIFNγIL-6IL-6 inhibitorIL6 ProteinIL6 inhibitorImmune InterferonImmunofluorescenceImmunofluorescence ImmunologicImmunofluorescence MicroscopyInflammationInflammatoryInheritedInterest GroupInterferon GammaInterferon Type IIInterleukin-6Interleukin-6 inhibitorIntracellular Communication and SignalingIon ExchangeKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLactone CompoundLactonesLecithinase A2Lecithinase BLecithinasesLightLinkLipaseLipid PeroxidationLipidsLysolecithin-Lysolecithin AcyltransferaseLysolecithinaseLysophospholipaseMGI-2Macrophage-Derived TNFMaintenanceMammaliaMammalsMeasuresMediatingMembraneMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsMiceMice MammalsMitochondriaModelingModern ManModificationMolecularMolecular InteractionMolecular Sieve ChromatographyMonocyte-Derived TNFMorphologyMurineMusMyeloid Differentiation-Inducing ProteinN-terminalNH2-terminalNegative Beta ParticleNegatronsNeoplasm MetastasisNeovascularization InhibitorsNeuronal DifferentiationNucleusNull MouseOncogenesisOuter pigmented layer of retinaOxidative StressOxygen RadicalsPEDFPEDF receptorPLA2PansyPeptidasesPeptide HydrolasesPeptidesPhosphatidesPhospholipasePhospholipase A2Phospholipase BPhospholipases APhospholipidsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPigment cell layer of retinaPigmented layer of retinaPlasmacytoma Growth FactorPlayPrecipitationPro-OxidantsProcessProductionPropertyProtease GeneProteasesProteinasesProteinsProteolytic EnzymesQuantitative RTPCRQuantitative Reverse Transcriptase PCRRT-PCRReactionReactive Oxygen SpeciesRecombinant ProteinsRecombinantsRegulationReplicative SenescenceReportingResearchRetinaRetinal DegenerationRetinal Pigment EpitheliumRetinal pigment epithelial cellsReverse Transcriptase Polymerase Chain ReactionRoleSamplingSecondary NeoplasmSecondary TumorSerpin SuperfamilyShockSignal TransductionSignal Transduction SystemsSignalingSize Exclusion ChromatographyStaining methodStainsStructure of retinal pigment epitheliumTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTranscriptTranscription Factor Proto-OncogeneTranscription factor genesTransmission Electron MicroscopyTriacylglycerolTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriglyceridesTriolean HydrolaseTumor Necrosis FactorTumor Necrosis Factor-alphaUpregulationViolaVioletVisual ReceptorWorkaffinity purificationage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophyaged miceaged mouseaminoacidantiangiogenicbiological signal transductioncDNAcancer metastasiscirculatory shockcomparativecrista ampullacristaecytokinedamage to retinadegenerative retina diseasesdevelopmentalearly PDL proteinearly population doubling level cDNA-1 proteinearly population doubling level proteinelderly miceenzyme linked immunoassayesterasefat metabolismhis6 tagiPSiPSCiPSCsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibit IL-6inhibit IL6inhibit Interleukin-6inhibitorinterferon beta 2lFN-Gammalecithinase Alife spanlifespanlipid metabolismmembermembrane structuremitochondrialmodel of animalmouse modelmurine modelmutantnecrocytosisneuronal survivalnovelold micephosphatidasephosphatidolipasephosphatidylcholine 2 acylhydrolasepigment epithelium-derived factorpigment epithelium-derived factor receptorprecipitationspreventpreventingprotein foldingqRTPCRreplicative agingretina degenerationretina ischemiaretinal damageretinal degenerativeretinal degenerative diseasesretinal ischemiareverse transcriptase PCRscreeningscreeningssenile macular diseasesexshockssocial roletranscription factortributyrasetumor cell metastasistumorigenesiszaprinast
Description preview
To explore the regulatory role played by the PEDF/PEDF-R axis in photoreceptor survival and lipid metabolism, we continued characterizing photoreceptors deficient in PEDF and PEDF-R. We used Pnpla2 knock-out mice crossbred with Serpinf1 null mice to generate wild type, Serpinf1+/-/Pnpla2-/- and Serpinf1-/-/Pnpla2-/- genotypes. Evaluations were…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click