grant
Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 5 Sept 2016Deadline 31 Jul 2031
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase1-Phosphatidylinositol 4-KinaseAKTATP-protein phosphotransferaseAkt proteinAmino AcidsAnti-OncogenesAntioncogenesAutomobile DrivingBody TissuesC-terminalCancer ControlCancer Control ScienceCancer Suppressor GenesCancersCellular ExpansionCellular GrowthCellular Metabolic ProcessComputer softwareDNA mutationDephosphorylationDrug TherapyEC 2.7.1.67EmerogenesEnzyme ActivationEnzyme GeneEnzymesEventFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FamilyFundingGene FamilyGeneralized GrowthGenesGeneticGenetic ChangeGenetic defectGenetic mutationGrantGrowthGrowth AgentsGrowth FactorGrowth SubstancesHLA-DR Associated Protein IIHumanHumulin RIGAADIGF1IGF1 geneIGFIInhibitor of GZMA-Activated DNaseInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsInsulinIntermediary MetabolismKinase Family GeneKinasesLengthLipidsMMAC1MMAC1 proteinMalignant NeoplasmsMalignant TumorManuscriptsMechanistic Target of RapamycinMediatingMetabolic ProcessesMetabolismModern ManMutated in Multiple Advanced Cancers 1MutationN-terminalNH2-terminalNPIKNatureNormal TissueNormal tissue morphologyNovolin ROnco-Suppressor GenesOncogenes-Tumor SuppressorsOncogenicOncogenic VirusesPHTS genePHTS proteinPI 4-KinasePI-3 KinasePI3-KinasePI3CGPI3K-AlphaPI3KGammaPI3kPI4K92PI4KBetaPIK3PIK3-AlphaPIK3CAPIK3CA genePIK3CGPIK3CG genePTENPTEN genePTEN proteinPTEN1PaperPharmacological TreatmentPharmacotherapyPhosphatase 2A Inhibitor I2PP2APhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10PhosphatesPhosphatidyl InositolPhosphatidylinositiol KinasePhosphatidylinositol 3-KinasePhosphatidylinositol 3-Kinase, Catalytic, 110-kD, AlphaPhosphatidylinositol 3-Kinase, Catalytic, AlphaPhosphatidylinositol 4-KinasePhosphatidylinositol 4-Kinase BetaPhosphatidylinositol 4-Kinase, Catalytic, BetaPhosphatidylinositol 4-Kinase, Type III, BetaPhosphatidylinositol Kinase Type IIPhosphatidylinositol-3-OH KinasePhosphatidylinositolsPhosphoinositide 3-HydroxykinasePhosphoinositide KinasePhosphoinositide-4-Kinase Catalytic Beta PolypeptidePhosphoinositidesPhosphorylationPhosphotransferase GenePhosphotransferasesPositionPositioning AttributeProcessProductionProtein DephosphorylationProtein KinaseProtein Kinase BProtein PhosphorylationProteinsProteins Growth FactorsProto-Oncogene Proteins c-aktPtdINS3PPtdInsPtdIns 3-KinasePtdIns 4-KinasePublishingRAC-PK proteinRAFT-1 gene productRAFT1Recessive OncogenesRegular InsulinResearchRoleSET Translocation Inhibitor-2 of Protein Phosphatase-2ASet proteinSoftwareSubstrate SpecificityTemplate Activating Factor I BetaTissue GrowthTissuesTransphosphorylasesTumor CellTumor Suppressing GenesTumor Suppressor GenesTumor VirusesType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseWorkWortmannin-Sensitive Phosphatidylinositol 4-Kinaseaminoacidc-akt proteincancer cell metabolismcancer metabolismcell growthcell metabolismcellular metabaolismdevelop softwaredeveloping computer softwaredrivingdrug interventiondrug treatmentgenome mutationglucose uptakeglycogen synthase a kinasehydroxyalkyl protein kinaseinhibitorinorganic phosphateloss of function mutationmTORmTOR gene productmTOR proteinmalignancymammalian target of rapamycinmutated in multiple advanced cancers 1 proteinneoplasm/cancerneoplastic celloncogenic tumor virusoncosuppressor geneontogenyp110-Alphapharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphosphatase and tensin homologue on chromosome tenphosphatidylinositol 3-monophosphatephosphatidylinositol 3-phosphatephospho-proteomicsphosphoproteomicsphosphorylase b kinase kinasepreventpreventingprotein kinase inhibitorproto-oncogene protein RACproto-oncogene protein aktrac protein kinaserelated to A and C-proteinsocial rolesoftware developmentsynthetic peptidetumor cell metabolismtumor metabolism
Description preview
Project Summary/Abstract
Previous work funded by this R35 grant led to the discovery that oncogenic viruses stimulate the production of
a set of lipids that were not previously known to exist: phosphatidylinositol-3-phosphate, phosphatidylinositol-
3,4-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate. This led to the discovery of the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click