grant
Role of obesity as a causative factor of breast cancer in women of African American ethnicity
Organization TUSKEGEE UNIVERSITYLocation TUSKEGEE INSTITUTE, UNITED STATESPosted 7 Jul 1997Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AddressAdmixtureAdoptedAdverse effectsAfricanAfrican AmericanAfrican American FemalesAfrican American WomenAfrican FemalesAfrican WomenAfrican ancestryAfrican descentAfro AmericanAfroamericanAgeAlabamaAmericanAsian ancestryAsian descentBehavioralBiologicalBiological MarkersBiomedical ResearchBlackBlack raceBreast CancerBreast Cancer PatientBreast Cancer Risk FactorBreast Tumor PatientCancer BiologyCancer BurdenCancersCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCaucasian FemalesCaucasian WomenCharacteristicsChronicClinicClinicalCommunitiesComplexDataDeath RateDiseaseDisease ProgressionDisorderDisparitiesDisparityEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEthnic OriginEthnicityEuropeanGenesGeneticGenomicsGoalsHealth Care ProvidersHealth PersonnelHealth ServicesHealth systemHigh PrevalenceImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectIncidenceIndividuals from minorityIndividuals of minorityInequityInferiorInflammationInflammatoryInfrastructureInterdisciplinary ResearchInterdisciplinary StudyInterventionIntratumoral heterogeneityLinkMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMedical ElectronicsMethylationMinority GroupsMinority PeopleMinority PopulationMinority individualMolecularMorbidityMorbidity - disease rateMultidisciplinary CollaborationMultidisciplinary ResearchNational Cancer BurdenNatureNutritionalObesityOncologyOncology CancerPathologyPatient Self-ReportPatientsPhenX ToolkitPhenotypePhenotypes and eXposures ToolkitPhenxPlayPopulationProtocolProtocols documentationRaceRacesRecordsRiskRisk FactorsRoleSamplingSelf-ReportSeveritiesSurvey InstrumentSurveysTNBCTumor BiologyUniversitiesWhite FemalesWhite WomenWorkadiposityadvanced diseaseadvanced illnessagesanti-cancer researchbio-markersbiologicbiologic markerbiomarkerbreast cancer progressionbreast cancer riskcancer carecancer progressioncancer researchcancer survivalcase-controlled studiescell typecorpulencedata integrationdata modalitiesdifferences due to racedifferences in racedifferential expressiondifferentially expresseddiffers by racediffers in racedisparate effectdisparate impactdisparate resultdisparities in mortalitydisparities in racedisparity due to racedisparity in healthentire genomeenvironmental riskenvironmental stressesenvironmental stressorepigeneticallyethnic minorityevidence baseexperiencefemale outcomesfull genomegenome sequencinghealth care personnelhealth care workerhealth disparityhealth providerhealth workforceheterogeneity in tumorsimage-based methodimaging methodimaging modalityimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentindividuals with breast cancerinequality due to raceinequitable effectinequitable impactinequitable outcomeinequity due to raceinnovateinnovationinnovativeintra-tumoral heterogeneityintratumor heterogeneitymalignancymalignant breast tumormarginalizationmedical personnelminority patientmortalitymortality disparitymortality ratemortality ratiomultiplexed imagingneoplasm progressionneoplasm/cancerneoplastic progressionnovelnutritiousobesigenicobesogenicoutcome disparitiesoutcome inequalityoutcome inequityoutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenpatient centeredpatient orientedpatient populationpatients from minoritypatients of minoritypatients with breast cancerperson with breast cancerprogramsrace based differencesrace based disparityrace based inequalityrace based inequityrace differencesrace disparityrace related differencesrace related disparityrace related inequalityrace related inequityracialracial backgroundracial differenceracial disparityracial inequalityracial inequityracial minorityracial originracially differentracially unequalresponse to therapyresponse to treatmentsocialsocial factorssocial health determinantssocial rolespectral imagespectral imageryspectrographspectrum imagespectrum imagerysystemic inflammationsystemic inflammatory responsetherapeutic responsetherapy responsetranscriptional differencestreatment providertreatment responsetreatment responsivenesstriple-negative breast cancertriple-negative invasive breast carcinomatumortumor heterogeneitytumor immune microenvironmenttumor progressiontumor-immune system interactionsunequal effectunequal impactunequal outcomewhole genomewomen's outcomesyounger age
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PROJECT SUMMARY
Breast cancer (BC) is not only a heterogenous disease by itself but it also has a differential racial impact. Prognostically, it has an inferior outcome in African American (AA) patients descent as compared to European American. BC in African ancestry presents at a younger age and is associated with more advanced disease and…
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