grant
Role of NOTCH2 in Articular Inflammation
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 14 May 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026(TNF)-αAffectB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor GeneB-Cell Differentiation Factor-2B-Cell Stimulatory Factor 2 GeneB-Cell Stimulatory Factor-2BCDFBSF-2BSF-2 GeneBSF2BSF2 GeneBeta Proprotein Interleukin 1Beta-2 Gene InterferonCachectinCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsChondrocytesDNA RecombinationDNA mutationDegenerative ArthritisDegenerative polyarthritisDevelopmentDrosophila Homolog of NOTCH 1ExhibitsGenesGenetic ChangeGenetic RecombinationGenetic defectGenetic mutationGoalsHPGFHSF GeneHepatocyte Stimulatory Factor GeneHepatocyte-Stimulating FactorHumanHybridoma Growth FactorHybridoma Growth Factor GeneIFN-beta 2IFNB2IFNB2 GeneIL-1 betaIL-1 βIL-1-bIL-1βIL-6IL-6 GeneIL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6IL6 ProteinIL6 geneIn VitroInflammationInflammatory ResponseInterleukin 1betaInterleukin 6 (Interferon, Beta 2) GeneInterleukin-1 betaInterleukin-1βInterleukin-6Interleukin-6 GeneIntracellular Communication and SignalingInvestigationJob LocationJob PlaceJob SettingJob SiteJointsMGI-2Macrophage-Derived TNFMedial MenisciMedial meniscus structureMembrana Synovialis Capsulae ArticularisMeniscus MedialisMiceMice MammalsModelingModern ManMolecular FingerprintingMolecular ProfilingMonocyte-Derived TNFMurineMusMutant Strains MiceMutationMyelogenousMyeloidMyeloid Differentiation-Inducing ProteinNOTCH1NOTCH1 geneNotch Signaling PathwayOperative ProceduresOperative Surgical ProceduresOsteoarthritisOsteoarthrosisPathogenesisPathway interactionsPhagosomesPhenotypePlasmacytoma Growth FactorPositionPositioning AttributePreinterleukin 1 BetaProteolysis and Signaling Pathway of NotchRNA SeqRNA sequencingRNAseqReceptor ProteinRecombinationResearchResolutionRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStudy modelsSurgicalSurgical InterventionsSurgical ProcedureSynovial CellSynovial MembraneSynoviumTAN1TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTranslationsTranslocation-Associated NOTCH HomologTraumatic ArthritisTraumatic ArthropathyTumor Necrosis FactorTumor Necrosis Factor-alphaWorkWork LocationWork PlaceWork-SiteWorkplaceWorksitebiological signal transductionchronic inflammatory diseasedegenerative joint diseasedevelopmentalgain of functiongenome mutationglobal gene expressionglobal transcription profilehypertrophic arthritisin vivointerferon beta 2molecular profilemolecular signaturemouse modelmouse mutantmurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnotchnotch proteinnotch receptorsnotch-2 proteinnotch2 proteinnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypost-traumatic osteoarthritispreventpreventingreceptorresolutionssocial rolesubchondral bonesurgerytranscriptometranscriptome sequencingtranscriptomic sequencingtranslationwork setting
Description preview
PROJECT SUMMARY/ABSTRACT
Osteoarthritis is a chronic inflammatory and degenerative disease of the joint affecting the cartilage,
synovium and subchondral bone. Notch signal activation has been associated with the development of
osteoarthritis, and inactivation of its canonical signaling prevents the osteoarthritis that follows destabilization
of…
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