grant
Role of microglial ferritinophagy in HIV and cocaine-mediated neuroinflammation
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 15 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AIDS VirusAIDS progressionAIDS/HIVARA70ARA70/ELE1Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcquired brain injuryActive OxygenAffectAndrogen Receptor-Associated ProteinAndrogen Receptor-Specific CoactivatorAssayAttenuatedAutophagocytosisAutopsyAutoregulationBehavioralBehavioral AssayBioassayBiological AssayBody TissuesBrainBrain InflammationBrain InjuriesBrain Nervous SystemBrain PathologyBrain regionCNS DiseasesCNS disorderCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous System DiseasesCentral Nervous System DisordersChronicClinicalCocaineCocaine misuseCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDataDisturbance in cognitionDrug abuseDysfunctionELE1EncephalitisEncephalonEquilibriumExhibitsExposure toFe elementFe metabolismFe overloadFerritinFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFunctional disorderGene TranscriptionGenerationsGenetic TranscriptionGoalsHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV disease progressionHIV individualsHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV infected individualsHIV infected personsHIV neurocognitive impairmentHIV peopleHIV positive individualsHIV positive peopleHIV progressionHIV viral infectionHIV virus infectionHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 disease progressionHIV-1 infectionHIV-IHIV-associated neurocognitive disorderHIV/AIDSHIV/AIDS progressionHIV1HomeostasisHortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ImmuneImmune signalingImmunesImpaired cognitionImpairmentIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammasomeInflammatoryIntracellular Communication and SignalingIronIron OverloadKnowledgeLAV-HTLV-IIILinkLipid PeroxidationLymphadenopathy-Associated VirusLysosomesMacacaMacaqueMediatingMediatorMemoryMiceMice MammalsMicrogliaModern ManModernizationMolecularMurineMusNCOA4 ProteinNNTCNational NeuroAids Tissue ConsortiumNeurocognitionNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1Neuronal InjuryNuclear Receptor Coactivator 4Oxidative StressOxygen RadicalsPLWHPWHPathologic ProcessesPathological ProcessesPathway interactionsPatientsPeripheralPersonsPhysiological HomeostasisPhysiopathologyPrevalencePro-OxidantsProcessProgress into acquired immunodeficiency syndromeProgress to acquired immunodeficiency syndromeProgression in HIVProgression in HIV-1Progression to AIDSProgression towards AIDSProteinsRET Activating Protein ELE1RNA ExpressionReactive Oxygen SpeciesRecoveryRegimenResearchRodentRodent ModelRodentiaRodents MammalsRoleSignal TransductionSignal Transduction SystemsSignalingSubstance Use DisorderSynapsesSynapticTestingTherapeuticThinkingTissuesTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranscriptionTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscriptional Activator/CoactivatorTransgenic MiceValidationViralViral Gene ProductsViral Gene ProteinsViral ProteinsViremiaVirus ReplicationVirus-HIVWorkabuse of drugsabuses drugsaccumulated exposureaccumulated long-term exposureacquired immunodeficiency syndrome progressionaggregate exposureantiretroviral therapyantiretroviral treatmentattenuateattenuatesautophagybalancebalance functionbiological signal transductionbrain cellbrain damagebrain healthbrain tissuebrain-injuredclinical developmentco-morbidco-morbiditycocaine exposurecocaine usecocaine-exposedcognitive dysfunctioncognitive losscomorbiditycumulative exposurecumulative life exposurecumulative long-term exposurecytokinedetermine efficacydisease modeldisorder modelefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperienceexposed to cocaineexposure to cocaineflow cytophotometryfunctional outcomesgitter cellglial activationglial cell activationhuman immunodeficiency virus infectionhuman immunodeficiency virus progressionin vivoindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusiron metabolismlife spanlife-course exposurelifelong exposurelifespanlifespan exposurelifetime exposuremesogliamicroglial cellmicrogliocytemouse modelmurine modelnecropsyneural inflammationneurocognitive disorderneuroinflammationneuroinflammatoryneuron injurynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwaypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusperivascular glial cellpostmortempreservationprogression to acquired immunodeficiency syndromepsychostimulant misusepsychostimulant usepsychostimulant use disorderresponserestorationsmall moleculesocial rolestimulant misusestimulant usestimulant use disordersubstance use and disordersynapsetherapy adherencetherapy compliancethoughtstotality of exposurestranslation strategytranslational approachtranslational opportunitiestranslational potentialtranslational strategyuse of stimulantsvalidationsviraemiaviral multiplicationviral replicationviral sepsisvirus multiplicationvirus proteinvirusemia
Description preview
Project Summary/Abstract: HIV/AIDS continues to affect nearly 39.9 million people worldwide. Although
combination antiretroviral therapy (cART) effectively suppresses viral replication and reduces progression to
AIDS, approximately 30–60% of people living with HIV (PLWH) still experience HIV-associated neurocognitive
disorders (NeuroHIV),…
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