grant
Role of Mertk in pathological neurodevelopment in mice with congenital Zika virus infection
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20260-11 years old2019 novel corona virus2019 novel coronavirus2019-nCoV21+ years oldAbscissionAcquired brain injuryAdultAdult HumanAffectAmericasAnimal ModelAnimal Models and Related StudiesApoptosisApoptosis PathwayApoptoticAstrocytesAstrocytusAstrogliaAutoimmuneAwardBehaviorBehavioralBiologic ModelsBiological ModelsBiologyBirthBrainBrain InjuriesBrain Nervous SystemBreedingCNS Nervous SystemCOVID-19 virusCOVID19 virusCalcifiedCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCase StudyCase-Base StudiesCausalityCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCentral Nervous SystemChildChild YouthChildhoodChildren (0-21)CoV-2CoV2CognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommunicable DiseasesDataDevelopmentDisease OutbreaksDisturbance in cognitionDysfunctionEbolaEncephalonEnvironmentEpidemicEtiologyExcisionExposure toExtirpationFlavivirusFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFunctional disorderFutureGene TranscriptionGenetic TranscriptionGestationGliaGlial CellsGoalsGroup B ArbovirusHortega cellHydrocephalusHydrocephalyIQ DeficitImage AnalysesImage AnalysisImmuneImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunotherapyImpaired cognitionInfantInfectionInfectious DiseasesInfectious DisorderInflammatory ResponseInjuryInstitutionInterventionIntracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsK12K12 AwardK12 MechanismK12 ProgramKO miceKnock-out MiceKnockout MiceKolliker's reticulumLeadLinkMER Tyrosine Kinase ProtooncogeneMERTKMERTK geneMacrophageMediatingMedical ImagingMentored Clinical Scientist Development ProgramMentorsMetabolic stressMethodsMiceMice MammalsMicrocephalyMicrogliaModel SystemModelingMonkey PoxMonkeypoxMothersMurineMusMφNerve CellsNerve UnitNeural CellNeural DevelopmentNeuraxisNeurocognitiveNeurocognitive DeficitNeurocyteNeurodevelopmental ImpairmentNeurodevelopmental ProblemNeurogliaNeuroglial CellsNeurologistNeuronal InjuryNeuronsNeurosciencesNeurosciences ResearchNon-neuronal cellNonneuronal cellNull MouseOrthoflavivirusOutbreaksOutcomePTK ReceptorsParturitionPathologicPathway interactionsPb elementPerinatalPerinatal InfectionPeripartumPhagocytosisPhysiciansPhysiopathologyPlayPopulationPregnancyProcessProgrammed Cell DeathProteinsPublicationsRNA ExpressionRadialRadiusReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneRemovalReportingResearchResearch Career ProgramResearch MethodologyResearch MethodsRestRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Scientific PublicationScientistSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Signal TransductionSignal Transduction SystemsSignalingSurgical RemovalSynapsesSynapticT-CellsT-LymphocyteTestingTimeTissue imagingTrainingTranscriptionTransmembrane Receptor Protein Tyrosine KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsViralViral DiseasesVirusVirus DiseasesWuhan coronavirusZIKVZIKV exposureZIKV infectedZIKV infectionZIKV positiveZIKV+Zika VirusZika exposureZika virus exposureZika virus infectionadult youthadulthoodanti-viral immunityantiviral immunityastrocytic gliabehavior outcomebehavior testbehavioral impairmentbehavioral outcomebehavioral testbiological signal transductionbrain abnormalitiesbrain circuitrybrain damagebrain injury in infantsbrain tissuebrain-injuredcalcificationcareercase reportcausationcognitive defectscognitive dysfunctioncognitive losscongenital ZIKV infectioncongenital Zika virus infectioncongenital infectioncongenital zika infectioncoronavirus disease 2019 viruscoronavirus disease-19 virusdevelopmentaldisease causationexposed in uteroexposure to ZIKVexposure to Zikaexposure to Zika virusfetalfetal exposureflow cytophotometrygitter cellhCoV19heavy metal Pbheavy metal leadhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhost responsehydrocephalichypoxic ischemic injuryimage evaluationimage interpretationimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoneurologyimmunoresponseimpaired behaviorimprovedimproved outcomein uteroin utero exposureinfant brain injuryinfant morbidityinfant morbidity/mortalityinfected with ZIKVinfected with zikainjuriesinnovateinnovationinnovativeintelligence quotient deficitintra-uterine environmental exposureintrauterine environmental exposurekidslymph organlymphatic organlymphoid organmesogliamicrencephalymicroencephalymicroglial cellmicrogliocytemodel of animalmotor deficitmouse developmentmouse modelmpoxmurine modelnCoV2necrocytosisnerve cementneural inflammationneurocognitive declineneurocognitive impairmentneurodevelopmentneuroimmunologyneuroinflammationneuroinflammatoryneuron injuryneuronalneurotropicneurotropic virusnoveloptic imagingoptical imagingpathogenpathophysiologypathwaypediatricperivascular glial cellpostnatalprenatalprenatal exposureprenatally exposedpupresearch and methodsresectionsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolesynapsesynaptic pruningtherapeutic agent developmenttherapeutic developmentthymus derived lymphocyteunbornviral disease outbreakviral infectionviral outbreakvirus disease outbreakvirus infectionvirus-induced diseaseyoung adultyoung adult ageyoung adulthoodyoungsterzika infectedzika infectionzika viral infectionzikav
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Project Summary/ Abstract
Congenital and perinatal infections are a leading cause of fetal and infant morbidity and mortality. There is
increasing evidence that brain injury in babies with congenital and perinatal infections is caused not only by direct
injury from the pathogen itself, but also may be due to the inflammatory or immune response to…
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