grant
Role of Macrophages in Inflammation and Degeneration of the Intervertebral Disc
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressBack AcheBack PainBackacheBehaviorBlood monocyteCCL2CCL2 geneCausalityCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsCellularityChemoattractantsChemokine, CC Motif, Ligand 2Chemotactic CytokinesChemotactic FactorsChemotaxinsChronicCirculationCommon Rat StrainsDichloromethylene DiphosphonateDiseaseDisease ProgressionDisorderECMEconomic BurdenEnzyme GeneEnzymesEtiologyExhibitsExtracellular MatrixExtracellular Matrix DegradationFibrosisGeneralized GrowthGoalsGrowthHomologous Chemotactic CytokinesHumanImmuneImmune systemImmunesInfiltrationInflammationInflammatoryInjuryIntercrinesIntervertebral Disc Degenerative DiseaseIntervertebral Disc Degenerative DisorderIntervertebral DiskIntervertebral disc structureIntracellular Communication and SignalingKnock-outKnockoutLiposomalLiposomesLow Back AcheLow Back PainLow BackacheLumbagoMCAFMCP-1MCP1MacrophageMarrow monocyteMechanicsMediatingMiceMice MammalsMicrobeadsMicrospheresModelingModern ManMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMurineMusMφNerveNociceptionOpiate AddictionOpiate DependenceOpiatesOpioidOutcomePainPain ControlPain TherapyPain managementPainfulPathologicPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatternPhasePuncture procedurePuncturesRatRats MammalsRattusResearchResidualResidual stateRoleSCYA2SIS cytokinesSeveritiesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Spinal painSpine painStructureSymptomsTestingTimeTissue Growthaggrecanbiological signal transductioncartilaginouscausationchemoattractant cytokinechemokineclodronatecombatcomplement chemotactic factorconditional knock-outconditional knockoutconventional therapyconventional treatmentcytokinedegenerated intervertebral discdegenerative disc diseasedisabilitydisc degenerationdiscogenic back paindiscogenic paindisease causationdisease severityglobal gene expressionglobal transcription profileimproved outcomein vivoin vivo Modelinflammatory environmentinflammatory milieuinhibitorinjuriesinjury responseintervertebral disk degenerationintervertebral disk injurymechanicmechanicalmigrationmonocytemouse modelmurine modelneutralizing antibodynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnociceptivenovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynucleus pulposusontogenyopioid addictionopioid dependenceopioid dependentpain behaviorpain interventionpain sensitivitypain treatmentpatient oriented outcomespatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesprotective effectreceptor bindingreceptor boundrecruitresponse to injuryscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalsocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsspinal disk injurysystemic inflammationsystemic inflammatory responsetherapeutic agent developmenttherapeutic developmenttime usetranscriptome
Description preview
Abstract
Discogenic back pain, is a leading cause of disability, and involves degenerative changes of the intervertebral
disc (IVD), including extracellular matrix (ECM) degradation, macrophage (Mɸ) infiltration, inflammation, and
pathological nerve ingrowth. Since only a small subset of patients responds favorably to conventional treatments
which…
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