grant
Role of interneurons in brain tissue oxygen regulation
Organization ENDEAVOR HEALTH CLINICAL OPERATIONSLocation EVANSTON, UNITED STATESPosted 1 Aug 2018Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidActive OxygenAffectAminalonAminaloneAreaAutomobile DrivingAutoregulationBOLD responseBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesBrainBrain HypoxiaBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsCerebral cortexConnector NeuronCyclic SomatostatinDataDomestic RabbitDrug TherapyEDRF SynthaseElectrophysiologyElectrophysiology (science)EncephalonEndothelium-Derived Growth Factor SynthaseEnsureEpilepsyEpileptic SeizuresEpilepticsFunctional MRIFunctional Magnetic Resonance ImagingGABAGene ExpressionGenerationsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneGuanylyl Cyclase-Activating Factor SynthaseHealthHomeostasisHyperoxiaHypoxiaHypoxicIntercalary NeuronIntercalated NeuronsInterneuron functionInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingInvestigationLaser-Doppler FlowmetryMeasurementMeasuresMediatorMedicineMethodsMiceMice MammalsModalityMurineMusNO SynthaseNatureNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeuropeptide TyrosineNeurophysiology / ElectrophysiologyNeurosciencesNeurotransmittersNitric Oxide SynthaseNitric-Oxide SynthetaseO elementO2 elementOryctolagus cuniculusOutputOxygenOxygen DeficiencyOxygen RadicalsPHM27PathologicPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPlayPro-OxidantsPublishingPyramidal CellsRabbitsRabbits MammalsReactive Oxygen SpeciesRegulationRoleSRIHSRIH-14Seizure DisorderSensorySignal TransductionSignal Transduction SystemsSignalingSomatosensory CortexSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSourceStimulusSystemTestingThalamic structureThalamusTherapeutic InterventionTissuesVascular DiseasesVascular DisorderVasoactive Intestinal PeptideVasoactive Intestinal PolypeptideVasointestinal PeptideVisual Cortexarterioleawakeaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionblood oxygenation level dependent responseblood vessel disorderbrain healthbrain oxygenationbrain tissuecell typecerebral oxygenationdesigndesigningdrivingdrug interventiondrug treatmentelectrophysiologicalepilepsiaepileptogenicfMRIgamma-Aminobutyric Acidglia signalingglial signalinggrowth hormone release inhibiting factorhyperoxygenationimprovedin vivoinsightinterdisciplinary approachintervention therapymultidisciplinary approachnerve signalingneural imagingneural signalingneuro-imagingneuroimagingneurological imagingneuronalneuronal signalingneuropeptide Yneurotransmissionoptogeneticspharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreservationpreventpreventingresponsesocial rolesomatosensorysomesthetic sensory cortexthalamictranscriptomicsvascularvascular dysfunctionvasculopathyvasomotionvisual corticalγ-Aminobutyric Acid
Description preview
The regulation of oxygen in brain tissue is a fundamental question in neuroscience and
medicine, as it is crucial for maintaining optimal brain function. GABAergic interneurons, which
provide inhibitory signals in the cerebral cortex, have been found to not only connect with other
neurons but also with arterioles, enabling them to control network…
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