grant
Role of hippocampal interneurons in aberrant neurogenesis and epilepsy after traumatic brain injury
Organization PORTLAND VA MEDICAL CENTERLocation PORTLAND, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY202521+ years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAcquired brain injuryAcuteAdultAdult HumanAffectAminalonAminaloneAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAreaArmed Forces PersonnelAutomobile DrivingAutoregulationBasket CellBrainBrain InjuriesBrain Nervous SystemBrain TraumaBrain regionCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCell BodyCell Communication and SignalingCell FunctionCell MaturationCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClinical DataCommunitiesConnector NeuronCornu AmmonisDataDentate FasciaDevelopmentDiseaseDisorderDysfunctionElectrophysiologyElectrophysiology (science)EncephalonEntorhinal AreaEpilepsyEpileptic SeizuresEpilepticsEpileptogenesisFailureFascia DentataFrequenciesFunctional disorderFundingFutureGABAGeneticGoalsGyrus DentatusHilarHippocampusHistologicHistologicallyHomeostasisInjuryIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionIntracellular Communication and SignalingInvestigatorsKnowledgeLabelLearningLifeLinkMeasuresMedialMediatingMediatorMedicalMembrane PotentialsMemoryMiceMice MammalsMiddle EastMilitaryMilitary PersonnelModelingMonitorMurineMusMyoepithelial cellNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurologic DisordersNeurological DisordersNeuronsNeurophysiology / ElectrophysiologyNeurosciencesOutputParvalbuminsPathogenesisPathway interactionsPatientsPharmacogeneticsPhasePhysiological HomeostasisPhysiopathologyPlayPopulationPost-Traumatic EpilepsyPost-Traumatic Seizure DisorderPredispositionPreventative strategyPrevention strategyPreventive strategyProcessProliferatingReceptor ProteinRecurrenceRecurrentRegulationResearchResearch PersonnelResearchersRestResting PotentialsRetroviral VectorRetroviridaeRetrovirus VectorRetrovirusesRoleSeizure DisorderSeizuresSignal TransductionSignal Transduction SystemsSignalingSliceStructureSubcellular ProcessSusceptibilitySynapsesSynapticTechniquesTemporal Lobe EpilepsyTestingTrainingTransgenic MiceTransmembrane PotentialsTraumaTraumatic Brain InjuryTraumatic EpilepsyVDCCVeteransViralVirus-RetrovirusVoltage-Dependent Calcium ChannelsWorkadult neurogenesisadulthoodbiological signal transductionbrain damagebrain-injuredcalcium indicatorcohortcombatcontrolled cortical impactdentate gyrusdevelopmentaldrivingelectrophysiologicalentorhinal cortexepilepsiaepileptiformepileptogenicexperienceexperimentexperimental researchexperimental studyexperimentsgamma-Aminobutyric Acidgranule cellhippocampalimprovedimproved outcomein vivoinjuredinjuriesinnervationmedial temporal areamedial temporal lobemesial temporal areamesial temporal lobemilitary populationmodel of animalmouse modelmurine modelnerve supplyneuroblastneurogenesisneurological diseaseneuronalneuronal circuitneuronal circuitryneurotransmitter releasenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoptogeneticspathophysiologypathwaypatient populationpharmacologicpreservationpresynapticpreventpreventingprogramsreceptorrecruitresponseselective expressionselectively expressedsham surgerysocial rolesynapsetherapeutic agent developmenttherapeutic developmenttranslation strategytranslational approachtranslational strategytranslational studytraumatic brain damagetreatment strategyγ-Aminobutyric Acid
Description preview
Abstract
Post-traumatic epilepsy (PTE) can result from combat-related traumatic brain injury
(TBI), a well-documented phenomenon that has caused substantial neurologic disease
in Veterans, most recently in relation to conflicts in the Middle East (>350,000 cases of
combat-related TBI since 2000). Unfortunately, current treatments for PTE are of…
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