grant
Role of Fn-14 receptor in TNF-induced inflammation and tissue destruction
Organization WASHINGTON STATE UNIVERSITYLocation PULLMAN, UNITED STATESPosted 17 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026(IFN) α(IFN)-α(IFN)α(TNF)-αAcuteAdverse ExperienceAdverse eventAffectAlferonAnti-Tumor Necrosis Factor TherapyAntibodiesArthritisAtrophic ArthritisAutoimmune DiseasesBioinformaticsBody TissuesCCL2CCL2 geneCCL5CD 120a AntigenCD120a AntigensCachectinCell BodyCell Communication and SignalingCell SignalingCell surfaceCellsChemokine (C-C Motif) Ligand 5Chemokine, CC Motif, Ligand 2ChronicCo-cultureCocultivationCocultureCoculture TechniquesComplexCytokine Signal TransductionCytokine SignalingD17S136EDNA Synthesis FactorDataDiseaseDisorderEndothelial Cell Growth FactorFGFFibroblast Growth FactorFibroblast Growth Factor Gene FamilyFibroblast Growth Regulatory FactorFibroblastsGene set enrichment analysisGenesGrowth AgentsGrowth FactorGrowth SubstancesHumanIFN AlphaIFN αIFN-GammaIFN-gIFN-αIFN-γIFNGIFNaIFNαIFNγImmuneImmune InterferonImmune infiltratesImmunesIncidenceInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInterferon Alfa-n3Interferon GammaInterferon Type IIInterferon-αInterstitial CollagenaseIntracellular Communication and SignalingInvadedLeukocyte InterferonLymphoblast InterferonLymphoblastoid InterferonMCAFMCP-1MCP1MGC17164MMP-1MMP-1Fibroblast CollagenaseMMP1Macrophage-Derived TNFMatrix Metalloproteinase-1MeasuresMediatingMediatorMembrana Synovialis Capsulae ArticularisMiceMice MammalsModelingModern ManMolecularMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMonocyte-Derived TNFMurineMusOB-cadherinOnset of illnessOpportunistic InfectionsPathogenesisPathway interactionsPatientsPhenotypePre-Clinical ModelPreclinical ModelsProcessProductionProliferatingProteinsProteins Growth FactorsPsoriasisPsoriasis ArthropathicaPsoriatic ArthritisRANTESRNA SeqRNA sequencingRNAseqRationalizationReceptor ProteinReceptor SignalingResistanceResistance developmentResistant developmentRheumatoid ArthritisRoleSCYA2SCYA5SIS deltaSIS-deltaSISdSeveritiesShort interfering RNASignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Small Inducible Cytokine A5Small Interfering RNASynovial MembraneSynoviumSystemT-Cell RANTES ProteinT-Cell Specific Protein p288TCP228TNFTNF ATNF AlphaTNF Receptor p55TNF geneTNF therapyTNF-alpha inhibitorTNF-sR55TNF-αTNF-α inhibitorTNF-α receptorTNFATNFARTNFR p60TNFR, 55-kDTNFR, 60-kDTNFR-ITNFR1TNFR55TNFR60TNFRSF1ATNFRSF1A ReceptorTNFRSF1A geneTNFalpha receptorTNFαTNFα inhibitorTNFα receptorTestingTherapeuticTimeTissuesTransgenic OrganismsTumor Necrosis FactorTumor Necrosis Factor Receptor 1Tumor Necrosis Factor Receptor 55Tumor Necrosis Factor TherapyTumor Necrosis Factor-alphaantagonismantagonistanti-TNF therapyanti-TNF-alpha therapyarthriticautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncadherin-11chip modelchip systemcollagen antibody induced arthritiscytokinedeveloping resistancedifferential expressiondifferentially expresseddisease onsetdisorder onsetefficacy testinggene signaturesgenetic signaturehuman modelimmune cell infiltratein vivoinflammatory disease of the intestineinflammatory disorder of the intestineinhibitorinsightintestinal autoinflammationintraperitonealknock-downknockdownlFN-Gammamigrationmodel of humannovelon a chipon chiposteoblast cadherinoverexpressoverexpressionpathwaypharmacologicpodoplaninpsoriasiformpsoriaticreceptorresistantresponserestorationrheumatic arthritissiRNAsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesstranscriptional differencestranscriptome sequencingtranscriptomic sequencingtransgenictumor necrosis factor alpha receptortumor necrosis factor receptor 1Atumor necrosis factor α receptortumor necrosis factor-alpha inhibitor
Description preview
PROJECT SUMMARY
Tumor necrosis factor (TNF)-α is a major inflammatory cytokine involved in the pathogenesis of several
autoimmune and inflammatory diseases, including rheumatoid arthritis (RA). Current approaches aim to curb
TNF-α-induced inflammation and tissue damage by treating patients with TNF-α inhibitors (specific antibodies or
soluble…
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