grant
Role of fibronectin in the morphogenesis of the cardiac outflow tract
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 15 Aug 2017Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20260-4 weeks old22q11 Chromosomal Microdeletion Syndrome22q11 Deletion Syndrome22q11.2 deletion syndrome22q11.2DS22q11DSAberrant ChromosomeAblationAccountingAdherens JunctionAdhering JunctionAdhesive JunctionAdhesivesAffectAnchoring JunctionAnteriorAortaApplications GrantsArchitectureArteriesAutosomal dominant Opitz G/BBB syndromeBasal Transcription FactorBasal transcription factor genesBiomechanicsBirthBirth DefectsBloodBlood Reticuloendothelial SystemBody TissuesCardiacCardiac MalformationCardiac arteryCaringCausalityCayler cardiofacial syndromeCell BodyCell Communication and SignalingCell ShapeCell SignalingCell-Extracellular MatrixCellsCellular MechanotransductionCessation of lifeChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosomal DisordersChromosome 22q11.2 deletion syndromeChromosome AberrationsChromosome Abnormality DisordersChromosome AlterationsChromosome AnomaliesChromosome DisordersChromosome abnormalityChronicCirculationCold-Insoluble GlobulinsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCongenital chromosomal diseaseCoronary arteryCytogenetic AberrationsCytogenetic AbnormalitiesCytotacinCytotactinDataDeathDeath RateDefectDevelopmentDi George syndromeDiGeorge SyndromeDiGeorge anomalyDiGeorge sequenceDorsalDouble Outlet Right VentricleECMEmbryoEmbryonicEngineering / ArchitectureEpithelial CellsEpitheliumEquilibriumEtiologyExhibitsExtracellular MatrixExtracellular Matrix ProteinsFN1FaceFibronectin 1FibronectinsFutureGene DeletionGeneral PopulationGeneral PublicGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGlycoproteinsGrant ProposalsHealthHeartHeart MalformationHeart arteryHexabrachionHumanIn VitroInfantInfant MortalityInfant Mortality TotalIntracellular Communication and SignalingLETS ProteinsLarge External Transformation-Sensitive ProteinLeadLeft VentriclesLeft ventricular structureLifeMechanical Signal TransductionMechanosensory TransductionMediatingMedicalMesodermMiceMice MammalsModelingModern ManMolecularMorbidityMorphogenesisMorphologyMovementMurineMusNewborn InfantNewbornsNuclearNuclear PoreNuclear TranslocationOperative ProceduresOperative Surgical ProceduresOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinParturitionPathogenesisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPericardialPericardial body locationPhenocopyPositionPositioning AttributeProcessPropertyPulmonary ArteryPulmonary artery structureRecombinant DNA TechnologyRegulationResearchRight VentriclesRight ventricular structureRoleRotationSedlackova syndromeShprintzen syndromeSideSignal TransductionSignal Transduction SystemsSignalingSurfaceSurgicalSurgical InterventionsSurgical ProcedureSurvival RateSyndromeTaussig-Bing AnomalyTenascinTenascin-CTestingTherapeuticTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransposition of Great VesselsTubeUnited Statesabnormal heart developmentalpha 2-Surface Binding Glycoproteinbalancebalance functionbiological signal transductionbiomechanicalbody movementcausationchromosomal defectchromosome defectcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationconotruncal anomaly face syndromecritical congenital heart diseasedeath among infantsdeath in first year of lifedeath in infancydeath in infantsdevelopmentaldisease causationearly childhoodfacesfacialfamilial third and fourth pharyngeal pouch syndromegene deletion mutationgenetically engineeredheavy metal Pbheavy metal leadimprovedin vivoinfant deathinfant demiseinfantile deathinsightmalformationmechanosensingmechanotransductionmigrationmorphogenetic processmortalitymortality in infantsmortality ratemutantnewborn childnewborn childrennovelpathwaypatient oriented outcomespharyngeal pouch syndromeprenatalprogenitorscreeningscreeningssocial rolesuperresolution microscopysurgerysurgery outcomesurgical outcomesurvival outcometargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthird and fourth pharyngeal pouch syndromethymic and parathyroid agenesis syndrometranscription factortransposition of great arteryunbornvelo-cardio-facial syndromevelocardiofacial syndromevelofacial hypoplasia
Description preview
PROJECT SUMMARY Congenital heart disease (CHD) is the most common birth defect, affecting
approximately 1% of newborns. About 25% of CHD patients require surgery within the first year of life
and often need lifelong medical care. Despite advances in surgical care, CHD mortality remains high,
highlighting the need for a better understanding of its…
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