grant
Role of fibroblasts in bladder mucosal function
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 10 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20262-photon microscopyAblationActinsActomyosinAfferent NeuronsAgingBladderBladder Urinary SystemBladder mucosaBody TissuesCell BodyCell Communication and SignalingCell SignalingCellsCellular MatrixCellular MechanotransductionChronicCollagenCollagen FiberConnective TissueCorynebacterium Diphtheriae ToxinCytoskeletal SystemCytoskeletonDTR ProteinDataDiphtheria ToxinDiphtheria Toxin SensitivityDiseaseDisorderEngineeringExhibitsFibroblastsFibrosisGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingHB-EGF precursorIntegrin BindingIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvoluntary MuscleIon ChannelIonic ChannelsKO miceKetamineKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLamina PropriaMYH10MeasurementMechanical Signal TransductionMechanicsMechanosensory TransductionMediatingMembrane ChannelsMiceMice MammalsMicroscopyMolecularMucosaMucosal TissueMucous MembraneMurineMusMyosin AMyosin BMyosin Heavy ChainsMyosin IIAMyosin IIBNerveNerve EndingsNerve FibersNerve Impulse TransmissionNerve TransmissionNervous SystemNeurogenic BladderNeurogenic Bladder DisorderNeurogenic Urinary Bladder DisorderNeurologic Body SystemNeurologic Organ SystemNeuronal TransmissionNeuropathic BladderNon-Muscle Myosin Type IIANon-Muscle Myosin Type IIBNonmuscle Myosin Type IIANonmuscle Myosin Type IIBNull MouseObstructionPDGFPDGF-APDGF-A proteinPDGF1PDGFAPDGFA genePDGFA proteinPatientsPhenotypePiezo 1Piezo 1 ion channelPiezo1Platelet-Derived Growth FactorPlatelet-Derived Growth Factor A ChainPlatelet-Derived Growth Factor Alpha PolypeptidePlayPopulationPositionPositioning AttributePreparationPrimatesPrimates MammalsProcessPropertyReportingRoleSensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSiteSmooth MuscleSpottingsSurfaceTestingTissuesTranscript Expression AnalysesTranscript Expression AnalysisUrinary Bladder Neurogenic DysfunctionUrinationUrotheliumafferent nerveanalyze gene expressionaxon signalingaxon-glial signalingaxonal signalingbiological signal transductioncellular myosin heavy chain Bdiphtheria toxin receptordiptheria toxin receptordriving forcegene expression analysisgene expression assayglia signalingglial signalingin vivoinsightintegrin boundinterstitial cellintracellular skeletonmechanicmechanicalmechanosensingmechanotransductionmicturitionmyosin heavy chainmyosin heavy chain-Bmyosin, heavy polypeptide 10, non-musclenerve signalingneural signalingneuronal signalingneurotransmissionnon-muscle myosinnon-muscle myosin heavy chain-Bnonmuscle myosinnovelplatelet-derived growth factor Apreparationsprotein expressionradiation cystitisradiation-induced cystitisselective expressionselectively expressedsensory nervesocial roletranscriptional profilingtranscriptomicstwo photon excitation microscopytwo photon microscopyurinary bladderviscoelasticity
Description preview
Although the viscoelastic properties of the bladder wall depend on it, and large numbers of
patients suffer from diseases that give rise to stiff, fibrotic bladders (e.g., neurogenic bladder,
outlet obstruction, underactive bladder, radiation cystitis), we know little about the bladder's
connective tissue including its constituent fibroblasts. We…
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