grant
Role of DYRK1A/MNB in synaptic growth and function
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 16 Jul 2013Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AD dementiaASDAbscissionAffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaAutismAutistic DisorderAutophagocytosisBiologic ModelsBiological ModelsBipolar Affective PsychosisBipolar DisorderCalciumCalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalmodulinClathrinCommunicationDataDegenerative Neurologic DisordersDementiaDense Core VesicleDiseaseDisorderDown SyndromeDrosophilaDrosophila genusEarly Infantile AutismEmotionsEndocytosisEnsureEnzyme GeneEnzymesExcisionExtirpationFTD/ALSFTLD/ALSFliesFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisFutureGeneHomologGeneralized GrowthGrowthHomologHomologous GeneHomologueInfantile AutismIntellectual disabilityIntellectual functioning disabilityIntellectual limitationKanner's SyndromeKinasesLabelLangdon Down syndromeLearningLinkLocomotionManic-Depressive PsychosisMediatingMemoryMethodsMicrocephalyModel SystemModelingMolecularMongolismMonitorNerve CellsNerve DegenerationNerve UnitNervous SystemNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural DevelopmentNeural TransmissionNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurodevelopmental DisorderNeurologicNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic DisordersNeurologic Organ SystemNeurologicalNeurological Development DisorderNeurological DisordersNeuron DegenerationNeuronsNeuropeptidesOrganism-Level ProcessOrganismal ProcessOutputPARK20Pathway interactionsPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary Senile Degenerative DementiaProtein ModificationProtein PhosphorylationProteinsQuality ControlRecyclingRegulationRemovalResearchRoleSYNJ1SYNJ1 geneSleepSpecificitySurgical RemovalSynapsesSynapticSynaptic TransmissionSynaptic VesiclesSynaptic plasticityTDP-43 aggregateTDP-43 aggregationTDP43 aggregateTDP43 aggregationTestingTherapeuticTherapeutic InterventionTissue GrowthToxic effectToxicitiesTransphosphorylasesTrisomy 21Tyrosine PhosphorylationVesicleWorkamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdautism spectral disorderautism spectrum disorderautistic spectrum disorderautophagybipolar affective disorderbipolar diseasebipolar illnessbipolar mood disorderchromosome 21 trisomychromosome 21 trisomy syndromecombatcongenital acromicria syndromedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesflyfrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar dementia amyotrophic lateral sclerosisfruit flyin vivoinnovateinnovationinnovativeinsightintellectual and developmental disabilityintervention therapylimited intellectual functioningmanic depressive disordermanic depressive illnessmicrencephalymicroencephalymorbus Downneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurodevelopmentneurodevelopmental diseaseneurological degenerationneurological diseaseneuronalneuronal degenerationneurotransmitter releasenew approachesnovelnovel approachesnovel strategiesnovel strategyontogenypathwaypreservationpreventpreventingprimary degenerative dementiaprotein homeostasisproteostasispseudohypertrophic progressive muscular dystrophyresectionsenile dementia of the Alzheimer typesocial rolesynapsesynapse functionsynaptic functionsynaptojaninsynaptojanin-1synaptojanin1syntaxintooltraffickingtrisomy 21 syndromevesicle releasevesicular release
Description preview
PROJECT SUMMARY
The nervous system fine-tunes synaptic output to ensure reliable communication, partly through kinase-drive
protein phosphorylation. Alterations in phosphorylation dynamics profoundly affect neurotransmitter release,
synaptic vesicle recycling, synaptic growth and plasticity, and are closely associated with neurodevelopmental
and…
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