grant
Role of DNA structural dynamics in mutagenesis and oncogenesis
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Sept 2010Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureAddressAntioncogene Protein p53Automobile DrivingBasal Transcription FactorBasal transcription factor genesBase PairingBase SequenceBindingBiochemicalBiochemical ProcessBiochemical ReactionCancer CauseCancer EtiologyCancersCellular Tumor Antigen P53DNADNA BindingDNA Binding InteractionDNA Damage RepairDNA Data BanksDNA DatabanksDNA DatabasesDNA RepairDNA SequenceDNA boundDNA mutationDNA-Binding ProteinsDNA-Protein InteractionData BasesDatabasesDeoxyribonucleic AcidDevelopmentDiagnosisDiseaseDisorderEnzymatic ReactionEvolutionExhibitsG-T Mismatch-Specific Thymine DNA GlycosylaseGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic DiseasesGenetic DiversityGenetic VariationGenetic defectGenetic mutationGenetics-MutagenesisGenome StabilityGenomic StabilityGoalsHumanIn VitroKnowledgeLinkMaintenanceMalignant NeoplasmsMalignant TumorMapsMeasuresModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyMutationNucleosomesNucleotide SequenceNucleotidesOncogenesisOncoprotein p53Other GeneticsOutcomeP53PatternPhosphoprotein P53Phosphoprotein pp53PolymerasePopulationProbabilityProcessProtein TP53ProteinsPublic HealthResearchResearch ResourcesResolutionResourcesRoleShapesTP53TP53 geneTRP53TechniquesTechnologyTestingThermodynamicThermodynamicsThymine DNA GlycosylaseThymine Glycol DNA GlycosylaseThymine Glycol GlycosylaseTranscription Factor Proto-OncogeneTranscription factor genesTumor Protein p53Tumor Protein p53 GeneUnscheduled DNA Synthesisbasebasesbiophysical approachesbiophysical methodologybiophysical methodsbiophysical techniquescancer cell genomecancer genomecomputer based predictionconformationconformationalconformational stateconformationallyconformationsdata basedevelopmentaldriver lesiondriver mutationdrivingdriving forceemerging sequencing technologygenetic conditiongenetic disordergenome mutationgenome scalegenome-widegenomewidehuman errorimprovedin vivokinetic modelmalignancyneoplasm/cancernew sequencing technologynovel sequencing technologynucleic acid sequencep53 Antigenp53 Genesp53 Tumor Suppressorpredictive modelingprotein p53public health relevancerepairrepairedresolutionssocial rolethree dimensional structuretranscription factortumor genometumorigenesisyeast genome
Description preview
Project Summary
Mutations are fundamental to evolution, yet they can also cause cancer and various genetic disorders. Despite
their significance, our understanding of processes which generate or defend against mutations is incomplete.
We don’t understand why the probability of a base substitution mutation varies by many orders of magnitude…
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