grant
Role of Disadvantage, Mutographs and T Cell Immunity on MGUS in African Americans
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAffectAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAgeAmericanAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingBiologicalBlackBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBlood Plasma CellBone MarrowBone Marrow Reticuloendothelial SystemCancersCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCausalityCell FractionCensusesChromatin StructureClinicalComplexCriminal JusticeDNA SequenceDNA mutationDataDisadvantagedDiseaseDisorderDisparitiesDisparityEarly DiagnosisEconomic IncomeEconomical IncomeEducationEducational aspectsElementsEmploymentEnvironmental ExposureEtiologyEuropeanEuropean ancestryEventExclusionFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFoundationsFreezingFunctional RNAGenetic ChangeGenetic defectGenetic mutationGenomicsGeographyGoalsGroups at riskHealthHematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHistoryHousingImmune responseImmunityImmunoglobulin V(D)J RearrangementImpoverishedIncidenceIncomeIndividualInequityInflammatoryInvestigationKnowledgeLengthMGUSMalignant Hematopoietic NeoplasmMalignant NeoplasmsMalignant TumorMeasuresMediatingMemory B CellMemory B-LymphocyteModelingMonitorMonoclonal Gammopathy of Undetermined SignificanceMonoclonal Gammopathy of Unknown SignificanceMonoclonal gammopathy of uncertain significanceMultiple MyelomaMutationNoncoding RNANontranslated RNAOccidentalPBMCParticipantPatientsPeople at riskPeripheral Blood Mononuclear CellPersons at riskPlasma CellsPlasma-Cell MyelomaPlasmacytesPopulationPopulation HeterogeneityPopulations at RiskPovertyPrecancerous ConditionsPremalignant ConditionPremalignant StateRacial GroupRecording of previous eventsResearch ResourcesResourcesRiskRisk FactorsRoleSingle Base PolymorphismSingle Nucleotide PolymorphismSingle base substitutionSocial EnvironmentStandardizationStructural RacismT cell responseT-CellsT-LymphocyteTestingTimeTransportationUntranslated RNAV(D)J RearrangementV(D)J RecombinationVDJ rearrangementVDJ recombinationVariantVariationVulnerable Populationsagesassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicblood cancerbuilt environmentcancer of bloodcancer of the bloodcase controlcase-controlledcausationdisease causationdisease disparitydiverse populationsdrivingearly detectionentire genomeexhaustionflow cytophotometryfull genomegene signaturesgenetic signaturegenome mutationgenome sequencingheterogeneous populationhistorieshost responseimmune system responseimmunoresponseimprovedincomesindelindexinginnovateinnovationinnovativeinsertion/deletioninsertion/deletion mutationmalemalignancymalleable riskmarginalized groupmarginalized individualmarginalized peoplemarginalized populationmethods to study multiple-level influencesmodifiable riskmortalitymulti-level analysismulti-level modelmultilevel analysismultilevel modelmultilevel modelingmyelomamyelomatosisneo-antigenneo-epitopesneoantigensneoepitopesneoplasm/cancernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnoncodingnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpatient populationperipheral bloodplasmocytepopulation diversityprecancerous stateracial populationracial subgroupreceptor expressionresidential segregationruralitysexsingle nucleotide variantsocial climatesocial cohesionsocial contextsocial rolesocioenvironmentsocioenvironmentalstructural mutationstructural variantstructural variationtherapeutically effectivethymus derived lymphocytetoolvulnerable groupvulnerable individualvulnerable peoplewhite racewhole genome♂
Description preview
ABSTRACT
The goal of this investigation is to characterize the influence of structural racism on associations of mutational
signatures and T cell immunity on the excess risk of monoclonal gammopathy of undetermined significance (MGUS)
observed in African American (AA) populations. MGUS is a necessary precursor to Multiple Myeloma (MM), which
is…
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