grant
Role of Cryptosporidium effectors in host actin manipulation
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 5 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years oldActinsAddressAnimalsAssayBindingBioassayBiological AssayBiologyC parvumC. parvumCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCell Communication and SignalingCell SignalingCell membraneCellsCellular biologyCessation of lifeCharacteristicsChildChild YouthChildren (0-21)Clustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-ImmunoprecipitationsCryptosporidiosisCryptosporidiumCryptosporidium infectionCryptosporidium parvumCytoplasmCytoplasmic GranulesCytoplasmic MembraneDataDeathDiarrheaDisease OutbreaksDrugsEpithelial CellsF-ActinFilamentous ActinFutureGene AlterationGene DeletionGene MutationGenesGeneticGoalsHandHumanHydrogen OxideImmunityImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIndividualInfectionIntracellular Communication and SignalingInvadedKnock-outKnockoutKnowledgeMedicationMiceMice MammalsMicroscopyModelingModern ManMolecularMolecular GeneticsMolecular InteractionMolecular MimicryMurineMusNamesOrganellesOutbreaksOutcomeParasitesPeptide Signal SequencesPharmaceutical PreparationsPlasma MembranePolymersProtein Binding DomainProtein Binding MotifProtein SecretionProtein-Protein Interaction DomainProteinsRecreationRoleSignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSporozoitesStructureSurfaceTM DomainTestingTransmembrane DomainTransmembrane RegionTwo HybridVAC-TXVaccine TherapyVaccinesVacuoleWaterWorkYeast One Hybrid SystemYeast One/Two-Hybrid SystemYeastsaccess to vaccinationaccess to vaccinesbiological signal transductioncandidate identificationcell biologydevelop a vaccinedevelop vaccinesdevelopment of a vaccinediarrheal diseasediarrheal illnessdrug/agenteffective therapyeffective treatmententeral infectionenteric infectionenteric pathogen infectionenteropathogen infectionenteropathogenic infectionexperimentexperimental researchexperimental studyexperimentsfitnessgene defectgene deletion mutationgranulehandsimmunosuppressed patientimprovedinfected with Cryptosporidiuminfected with enteropathogeninnovateinnovationinnovativeinsightintestinal epitheliumintestinal infectionintestine infectionkidsmortalitymutantmutant allelenamenamednamingparasite invasionplasmalemmapolymerpolymericpolymerizationpressurepreventpreventingprotein signal sequencerhoptrysecretory proteinsocial roletherapeutic vaccinationvaccination accessvaccination availabilityvaccine accessvaccine availabilityvaccine developmentyeast 2-hybridyeast two hybrid systemyoungster
Description preview
Project Abstract
The protozoan parasite Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death in
young children and immunocompromised individuals. Currently, there are no vaccines or effective drugs to
prevent or treat cryptosporidiosis. Our understanding of the interactions of Cryptosporidium with its host cell is…
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