grant
Role of cardiac clock misalignment in promoting arrhythmias in swine and donor human hearts
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 5 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AcuteAddressAdrenergic AgentsAdrenergic DrugsAdrenergicsAdverse ExperienceAdverse eventAnteriorArrhythmiaAsystoleAttenuatedBody TissuesCalcineurinCalciumCalcium-Dependent Activator ProteinCalcium-Dependent RegulatorCalmodulinCardiacCardiac ArrestCardiac ArrhythmiaCardiac DiseasesCardiac DisordersCardiac Electrophysiologic TechniquesCardiac Electrophysiological DiagnosticsCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCatecholaminesCell BodyCell Communication and SignalingCell SignalingCellsChronicChronotherapyCircadian DysregulationCircadian RhythmsCircadian desynchronyClock proteinCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisCouplingDependenceDiurnal RhythmDrug TherapyEventExhibitsExposure toFamily suidaeFrequenciesGene TranscriptionGenesGenetic TranscriptionHeartHeart ArrestHeart ArrhythmiasHeart DiseasesHeart VascularHourHumanIncidenceIntracellular Communication and SignalingIschemiaIschemic HeartIschemic Heart DiseaseIschemic myocardiumLeftLifeLinkMalignantMalignant - descriptorMapsMediatingModern ManMolecularMyocardial IschemiaNF-ATNF-AT proteinsNFAT proteinsNFAT-1NFATC proteinsNyctohemeral RhythmOpticsPP2BPathological ConstrictionPathway interactionsPatientsPharmacological TreatmentPharmacotherapyPhasePhosphatasesPhosphodiesterase Activating FactorPhosphodiesterase Protein ActivatorPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPigsPlayPredispositionPremature Ventricular BeatsPremature Ventricular ContractionsProtein Phosphatase-2BProteinsProteomicsRNA ExpressionReperfusion TherapyRoleSERCA2aSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSliceStenosisStressSuidaeSusceptibilitySwineSympathinsSymptomsTechniquesTestingTimeTissuesTranscriptionTwenty-Four Hour RhythmVentricular ArrhythmiaVentricular Ectopic BeatsVentricular ExtrasystoleVentricular Premature ComplexesVentricular Premature ComplicesWorkatherosclerotic coronary diseaseattenuateattenuatesattenuationawakebiological signal transductioncardiac electrophysiologycardiac ischemiacircadiancircadian abnormalitycircadian clockcircadian desynchronizationcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian misalignmentcircadian pacemakercircadian processcircadian regulationcircadian rhythmicitycirculatory systemcoronary arterial diseasecoronary ischemiacytoplasmic nuclear factor of activated T-cellsdaily biorhythmdesigndesigningdiurnal variationdrug interventiondrug treatmentexperimentexperimental researchexperimental studyexperimentsheart disorderheart electrophysiologyheart ischemiahemodynamicsin vivoinsightmortalitymultiomicsmultiple omicsmyocardial ischemia/hypoxiamyocardium ischemianuclear factors of activated T-cellsopticaloverexpressoverexpressionpanomicspathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphospho-proteomicsphosphoproteomicspig modelpiglet modelporcineporcine modelpreventpreventingreperfusionsocial rolesuidswine modeltherapeutic targettranscription factor NF-ATtranscriptome profilingtranscriptomic profiling
Description preview
PROJECT ABSTRACT
Sudden cardiac arrest (SCA) due to malignant ventricular arrhythmias remains a major cause of mortality in
the US. While the majority of SCA patients have significant coronary artery disease (CAD), nearly one in three
patients present with lethal arrhythmias as their first and only manifestation of heart disease without prior…
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