grant
Role of Activin Type II Receptor Signaling in Muscle Hypertrophy, Obesity, and Weight Loss
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AbscissionActivinsAdipocytesAdipose CellAdipose tissueAdoptedAgonistAnimalsAnorectic DrugAnorectic agentAnorecticsAnorexiantAnorexic DrugsAnorexient AgentAnorexient DrugAnorexigenic DrugsAnti-Obesity AgentsAnti-Obesity DrugsAppetite DepressantsAppetite SuppressantsAppetite-Depressing DrugsAppetite-Suppressant DrugsBindingBlocking AntibodiesBody CompositionBody TissuesBody Weight decreasedBone-Derived Transforming Growth FactorCaloriesCell Communication and SignalingCell SignalingDataDefectDietDoseEYDFEatingEnergy ExpenditureEnergy MetabolismExcisionExtirpationFSH-Releasing ProteinFat CellsFatsFatty TissueFatty acid glycerol estersFiberFibrosisFood IntakeFoundationsFutureGDF-8GDF8GDF8 geneGIP receptorGLP-1GLP-1 receptorGLP-I receptorGene Action RegulationGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneralized GrowthGeneticGenetic TranscriptionGlp-1Glucose-Dependent Insulinotropic PolypeptideGoalsGrowthGrowth Differentiation Factor 8 GeneGrowth/Differentiation Factor 8HealthHeat ProductionHigh Fat DietHumanHypertrophyInflammationIntermediary MetabolismIntracellular Communication and SignalingIsotopesKnowledgeLeannessLigandsLipidsLipocytesMSTNMature LipocyteMature fat cellMeasuresMediatingMetabolicMetabolic ProcessesMetabolismMethodsMiceMice MammalsMilk Growth FactorMitochondriaModern ManMolecularMolecular InteractionMorphologyMurineMusMuscleMuscle AtrophyMuscle CellsMuscle ProteinsMuscle TissueMuscle functionMuscular AtrophyMyocytesNutrientObese MiceObesityPathway interactionsPhysical PerformancePhysiologyPlatelet Transforming Growth FactorPredispositionProteinsPublishingRNA ExpressionReceptor InhibitionReceptor SignalingRegimenRemovalRodentRodentiaRodents MammalsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleStructureSurgical RemovalSusceptibilityTGF BTGF-betaTGF-βTGFbetaTGFβTherapeuticTherapeutic AgentsThermogenesisThinnessTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneType II Activin Receptor Like KinasesType II Activin ReceptorsVO2 maxVO2maxVoluntary MuscleWeightWeight GainWeight IncreaseWeight LossWeight ReductionWithholding Treatmentactivin Aadipocyte developmentadipocyte differentiationadiposeadiposityadult adiposityadult obesityadults with obesityanalyze gene expressionanorexic agentantagonismantagonistanti-obesity compoundsanti-obesity medicationsanti-obesity therapeuticsbariatric surgerybiological signal transductionbody weight gainbody weight increasebody weight losscardiometaboliccardiometabolismcessation of treatmentcohortcorpulencedietingdietsenergy balanceerythroid differentiation factorerythroid differentiation proteinexperimentexperimental researchexperimental studyexperimentsgastric bandinggastric bypass surgerygastric inhibitory polypeptide receptorgene expression analysisgene expression assayglucagon-like peptide 1glucagon-like peptide-1 receptorglucose-dependent insulinotropic polypeptide receptorgrowth-differentiation factor 8homo-activin Aimplantable gastric stimulation bandingimprovedin vivoinhibitorinsulin sensitivitymaximal oxygen uptakemitochondrialmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle hypertrophymuscle lossmuscle massmuscle strengthmuscle wastingmuscularmyostatinnext generationob/ob mouseobesity interventionobesity surgeryobesity therapyobesity treatmentontogenyoxidationpathwaypatient populationpharmacologicphase 2 studyphase II studypoor health outcomepreservationreduced health outcomeresectionresponseskeletalskeletal preservationsocial rolestomach staplingsynergismtranscriptional profilingtreatment cessationtreatment effectweight loss surgeryweight maintenanceweightswhite adipose tissueworse health outcomewt gainwt-lossyellow adipose tissue
Description preview
Project Summary
GLP-1 receptor agonists and GLP-1/GIP dual agonists profoundly decrease body weight in association with
significant cardiometabolic benefits. These therapeutic agents are being widely adopted for obesity treatment in
the U.S. Certainly, lowering fat mass is metabolically advantageous; however, reduction of lean mass, especially…
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