grant
Role of a novel human mast cell G protein coupled receptor in Allergy and Inflammation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 23 Sept 2016Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026Acne RosaceaAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAgonistAllergicAllergic asthmaAllergyAnimal ModelAnimal Models and Related StudiesAsthmaBackBindingBody TissuesBronchial AsthmaCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCas nuclease technologyCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsChargeChemotactic CytokinesChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCodeCoding SystemCouplingCryo-electron MicroscopyCryoelectron MicroscopyCutaneousCutaneous DisorderCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDNA mutationDermatosesDevelopmentDiseaseDisorderDorsumDrug AllergyDrug HypersensitivityElectron CryomicroscopyEuler-Gaddum Substance PExtrinsic asthmaG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsG-ProteinsGPCRGTP-Binding ProteinsGTP-Regulatory ProteinsGene TargetingGene TranscriptionGenerationsGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHivesHomologous Chemotactic CytokinesHumanHydrophobicityHypersensitivityIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneIgEImmuneImmunesImmunoglobulin EIn VitroInflammationInflammatoryIntercrinesInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Intracellular Communication and SignalingIsoformsKnock-inLigand BindingLungLung InflammationLung Respiratory SystemMarrow Mast CellMediatingMembraneMiceMice MammalsMicroscopyMissense MutationModelingModern ManMolecularMolecular InteractionMurineMusMutationNatureNeuropeptidesOrthologOrthologous GenePathogenesisPhenotypePhosphorylationPhosphorylation SitePneumonitisPre-Clinical ModelPreclinical ModelsProceduresProtein IsoformsProtein PhosphorylationPsoriasisPublishingPulmonary InflammationRNA ExpressionReactionReceptor InhibitionReceptor ProteinRegulationResearchResolutionRoleRosaceaSIS cytokinesSignal TransductionSignal Transduction SystemsSignalingSkinSkin DiseasesSkin Diseases and ManifestationsSourceStrains Cell LinesStructureSubstance PTestingTh-2 CellTh2 CellsTissue BasophilsTissuesTranscriptionTransfectionType 2 Helper CellUlcerated ColitisUlcerative ColitisUrticariaVariantVariationadapter proteinanti-microbial peptidearrestin Batopic asthmabeta-arrestinbiological signal transductionchemoattractant cytokinechemokinecryo-EMcryoEMcryogenic electron microscopycultured cell linecutaneous diseasecytokinedermal diseasedermal disorderdesensitizationdevelopmentaldisease phenotypeextracellularextrinsic allergic asthmafunctional lossgain of functiongenome mutationin vivoin vivo Modelinhibitorknockinloss of functionmast cellmastocytemembrane structuremissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmodel of animalneurokinin 1new therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpharmacologicprotein activationpsoriasiformpsoriaticreceptorreceptor internalizationrecruitresolutionsresponseskin disordersocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsβ-arrestin
Description preview
Summary:
Mast cells (MCs) are best known for their roles in IgE-mediated allergic disorders. However, the recent
identification of Mas-related G protein coupled receptor-X2 (MRGPRX2) in human cutaneous MCs (MrgprB2;
mouse counterpart) as the receptor for antimicrobial peptides, neuropeptides and chemokines has revolutionized
the way in which MCs…
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