grant
Role of a Fatty Acid Chaperone in Schwann Cell Myelination
Organization ALBANY MEDICAL COLLEGELocation ALBANY, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026Acetylcholine Receptor Inducing ActivityAction PotentialsAllium cepaAssayAxonBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBiopsyBreast Cancer Cell Differentiation Factor P45CMT1CMT3Cell Communication and SignalingCell SignalingChaperoneCharcot Marie DisorderCharcot Marie Muscular AtrophyCharcot Marie Tooth DisorderCharcot Marie Tooth muscular atrophyCharcot-Marie DiseaseCharcot-Marie-ToothCharcot-Marie-Tooth DiseaseCharcot-Marie-Tooth neuropathyCo-cultureCocultivationCocultureCoculture TechniquesComplexCongenital Hypomyelinating NeuropathyDNA RecombinationDNA mutationDataDefectDejerine-Sottas DiseaseDemyelinating DiseasesDemyelinating DisordersDemyelinationsDevelopmentDevicesDiseaseDisorderDown-RegulationEGR2EGR2 geneEconomicsFatigueFatty AcidsFiberFree Fatty AcidsFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic RecombinationGenetic defectGenetic mutationGenus HippocampusGoalsHMN Distal Type IHMSN IHMSN Type IHMSN Type IIIHMSN Type IsHereditaryHereditary Motor and Sensory Neuropathy Type IHereditary, Type III, Motor and Sensory NeuropathyHumanInheritedInherited NeuropathyInterventionIntracellular Communication and SignalingIsotopesKROX20KnowledgeLack of EnergyLifelong disabilityLipidsLoss of SensationLuciferase ImmunologicLuciferasesMediatingMediatorMetabolicMiceMice MammalsMitochondriaModern ManMolecularMolecular ChaperonesMolecular InteractionMorphologyMotorMurineMusMuscle WeaknessMuscular WeaknessMutationMyelinMyelin P0 ProteinMyelin Protein ZeroMyelin ProteinsMyelinated nerve fiberNDF ProteinNINDSNRG1 Gene ProductNRG1 ProteinNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerveNerve CellsNerve ConductionNerve Impulse TransmissionNerve TransmissionNerve UnitNervous SystemNeural CellNeural ConductionNeuregulin 1Neurilemma CellNeurilemmal CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronal TransmissionNeuronsNeuropathyNonesterified Fatty AcidsNumbnessOccupational TherapyOnionsOrthopedicOrthopedic Surgical ProfessionOrthopedicsP0 GlycoproteinP0 ProteinPNS DiseasesPainPainfulPathologicPathway interactionsPatient CarePatient Care DeliveryPatientsPeripheralPeripheral Nerve DiseasesPeripheral Nerve Myelin Protein ZeroPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPermanent disabilityPeroneal Muscular AtrophyPersonsPhysiatric ProcedurePhysical Medicine ProcedurePhysical TherapeuticsPhysical therapyPhysiologicPhysiologicalPhysiotherapyPrevalencePreventative strategyPreventative treatmentPreventionPrevention strategyPreventive strategyPreventive treatmentProductionPublic HealthQOLQuality of lifeRNA SplicingRecombinationRegulationRoleSchwann CellsSeahorseSensory And Motor Neuron-Derived FactorSignal TransductionSignal Transduction SystemsSignalingSite-Directed MutagenesisSite-Specific MutagenesisSplicingTargeted DNA ModificationTargeted ModificationTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesType 1 Charcot-Marie-Tooth DiseaseType I Charcot-Marie-Tooth DiseaseUpregulationWorkanalogaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionburden of diseaseburden of illnesscare for patientscare of patientscaring for patientsde-myelinating diseasesde-myelinating disordersdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdevelop therapydevelopmentaldisease burdenearly-onset CMTeconomiceffective therapyeffective treatmentextracellularfatty acid-binding proteinsgain of functiongenome mutationglia signalingglial signalinghereditary neuropathyimprovedin vivoinsightintervention developmentlipidomicsloss of functionmitochondrialmouse modelmurine modelmyelinationnerve signalingneural signalingneuromuscular functionneuronalneuronal signalingneuropathicneurotransmissionoverexpressoverexpressionpain reliefpalliativepathwaypre-clinicalpreclinicalpreventpreventingre-myelinatere-myelinationrelieve painremyelinateremyelinationresponsesocial roletherapy developmenttranscription factortreatment developmentuptake
Description preview
Charcot-Marie-Tooth disease (CMT) is a group of disorders and the most common inherited peripheral
neuropathy with a prevalence of 1:2500. Approximately 1,000 small mutations (missense, nonsense, small
deletion or insertion, splice alterations) in more than 40 genes are responsible for CMT. CMT severely
impacts
the
is
orthopedic
quality of life…
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