grant
Role for nuclear matrix proteins and DNA methylation for XCI maintenance in female lymphocytes
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 7 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Ab responseAllelesAllelomorphsAntibody FormationAntibody ProductionAssayAutoantibodiesAutoantigensAutoimmuneAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-Cell ActivationB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBS-seqBindingBinding ProteinsBioassayBiological AssayBiotinylationBisulfite-based sequencingCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqChromatinChronicComplexDNADNA MethylationDataDeoxyribonucleic AcidDiseaseDisorderDisproportionate number of femalesDisproportionate number of womenDisproportionately affects femalesDisproportionately affects womenDisproportionately impacts femalesDisproportionately impacts womenDisproportionately in femalesDisproportionately in womenDosage CompensationDosage Compensation (Genetics)Double-Stranded DNADysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsFemaleFunctional disorderGene Copy NumberGene DosageGene Down-RegulationGene ExpressionGene InactivationGene ModifiedGene SilencingGene TranscriptionGenesGeneticGenetic TranscriptionGoalsHET GeneHET proteinHSP27 Estrogen Responsive Element - and TATA Box-Binding ProteinHypermethylationIFNImmuneImmunesImmunityImpairmentIn VitroInflammationInterferon Type IInterferonsIntracellular Communication and SignalingLE CellLigand Binding ProteinLigand Binding Protein GeneLinkLupusLupus Erythematosus DisseminatusLupus erythematosus cellLymphatic cellLymphocyteLymphocyticLyonizationMaintenanceMediatingMethylationMiceMice MammalsModificationMolecularMolecular InteractionMurineMusNon-Polyadenylated RNANuclear LaminaNuclear Matrix ProteinsNuclear Matrix-Associated ProteinsNuclear Scaffold ProteinOligoOligonucleotidesPathway interactionsPatientsPhysiopathologyPredisposing FactorPredisposition genePristaneProcessProductionProtein BindingProtein MethylationProteinsPublishingRNARNA BindingRNA ExpressionRNA Gene ProductsRNA boundRegulator GenesRibonucleic AcidRoleSAFBSAFB geneSAFB1SLEScaffold Attachment Factor BSelf-AntigensSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSomatic CellSubcellular ProcessSusceptibility GeneSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTestingTherapeutic InterventionTranscriptTranscriptionTranscription RepressionTranscriptional Regulatory ElementsWorkX ChromosomeX InactivationX-Chromosome Inactivationactivated B cellsantibody biosynthesisautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive antibodyautosomebiological sexbiological signal transductionbisulfite sequencingbisulfite-seqbound proteincell imagingcellular imagingchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcohesincohesiondisease severitydisseminated lupus erythematosusds-DNAdsDNAentire genomeepigeneticallyfemale biasfemale predominancefemale preponderancefull genomegene modificationgene repressiongenetic trans acting elementgenetically modifiedimmunoglobulin biosynthesisin vivoinnovateinnovationinnovativeinsightintervention therapylupus-likelymph cellmalemouse modelmurine modelnoveloligosoverexpressoverexpressionpathophysiologypathwaypredisposing genepredominance in femalespredominance in womenpreservationpromoterpromotorregulatory generesponseself reactive antibodysocial rolesusceptibility allelesusceptibility locussusceptibility variantsystemic lupus erythematosistrans acting elementtranscriptional silencingwhole genomewomen's predominancewomen's preponderance♀♂
Description preview
Females are predisposed for developing systemic lupus erythematosus (SLE), but the underlying mechanisms
remain obscure. Females have two X-chromosomes and equilibration of X-linked gene dosage to that of males
(XY) occurs by X-Chromosome Inactivation (XCI), initiated and maintained by Xist RNA. The X-chromosome is
enriched for immunity-related…
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