grant
RNA splicing regulation during alcohol withdrawal
Organization LOYOLA UNIVERSITY CHICAGOLocation MAYWOOD, UNITED STATESPosted 16 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Absolute ethanolAffectAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcohol withdrawal syndromeAlcoholsAlternate SplicingAlternative RNA SplicingAlternative SplicingAmmon HornAntibodiesAnxietyAutomobile DrivingAutopsyAwardBehaviorBehavioralBig DataBigDataBindingBinding ProteinsBioinformaticsBrainBrain Nervous SystemBrain regionCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessChronicCommon Rat StrainsComplementary DNAComplexCornu AmmonisDarknessDataData ScienceDevelopmentDevelopment and ResearchDiagnosisDorsalETOHEncephalonEnvironmentEtOH drinkingEtOH useEthanolEthicsEthyl AlcoholExclusionExonsExtracellular Matrix ProteinsFunctional RNAFutureGene DeliveryGene ExpressionGenesGeneticGoalsGrain AlcoholGrantHeavy DrinkingHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHippocampusHumanImmune PrecipitationImmune responseImmunoprecipitationIndividualIntracellular Communication and SignalingInvestigatorsIsoformsKnowledgeLeadershipLearningLengthLigand Binding ProteinLigand Binding Protein GeneLightMediatingMental DepressionMessenger RNAMethylcarbinolModern ManMolecularMolecular InteractionMorphogenesisNGS MethodNGS systemNatureNerve CellsNerve ConductionNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeural ConductionNeurocyteNeuronal TransmissionNeuronsNon-Polyadenylated RNANoncoding RNANontranslated RNAOralPhasePhotoradiationProceduresProcessProductionProtein BindingProtein IsoformsProteinsR & DR&DRNARNA BindingRNA Gene ProductsRNA SeqRNA SplicingRNA boundRNA sequencingRNA-Binding ProteinsRNAseqRatRats MammalsRattusRegulationResearchResearch PersonnelResearchersRibonucleic AcidRibonucleoproteinsRoleSaccharoseSignal TransductionSignal Transduction SystemsSignalingSiteSpliceosomesSplicingSubcellular ProcessSucroseTechniquesTestingTrainingTranscriptTranslational ResearchTranslational ScienceUntranslated RNAVariantVariationViralViral VectorWithdrawalWorkWritingalcohol behavioralcohol exposedalcohol exposurealcohol induced behavioralcohol ingestionalcohol intakealcohol product usealcohol related behavioralcohol usealcohol use disorderalcohol withdrawalalcoholic beverage consumptionalcoholic drink intakeanxiety-like behavioraxon signalingaxon-glial signalingaxonal signalingbehavior testbehavioral testbiological signal transductionbound proteincDNAcareer developmentchronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestiondepressiondesigndesigningdevelopmentaldrink heavilydrinking behaviordrivingethanol behaviorethanol consumptionethanol drinkingethanol exposedethanol exposureethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol useethanol use disorderethanol withdrawalethicalexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexperienceexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkinggene manipulationgenetic manipulationgenetically manipulategenetically perturbglia signalingglial signalingheavy alcohol usehippocampalhost responseimmune system responseimmunoresponseinnovateinnovationinnovativeinsightknock-downknockdownloss of functionmRNAmRNA Expressionmalemorphogenetic processnecropsynegative affectnegative affectivitynerve signalingneural adaptationneural inflammationneural signalingneuroadaptationneurogenesisneuroinflammationneuroinflammatoryneuronalneuronal signalingneurotransmissionnext gen sequencingnext generation sequencingnextgen sequencingnoncodingnoveloverexpressoverexpressionpostmortempreferenceresearch and developmentshRNAshort hairpin RNAskillssmall hairpin RNAsocial rolesuccesstheoriestooltranscriptome sequencingtranscriptomic sequencingtranslation researchtranslational investigationwithdrawal from alcohol♂
Description preview
Project Summary/Abstract
One way in which chronic alcohol exposure produces neuronal adaptations is by changing gene expression.
These changes can influence alcohol-drinking behavior and may lead to the development of alcohol use
disorder (AUD). Additionally, during alcohol withdrawal, gene expression changes can contribute to the
development of…
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