grant
RNA modification and innate immune activation in HIV infection
Organization BOSTON UNIVERSITY MEDICAL CAMPUSLocation BOSTON, UNITED STATESPosted 8 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAIDS testAIDS/HIV testAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAffectAgingBinding SitesBioinformaticsBlood PlasmaBlood monocyteBody TissuesBostonBrainBrain Nervous SystemCell BodyCellsChronicCollaborationsCombining SiteComplicationCytoplasmDataDepositDepositionEncephalonGene TranscriptionGenetic TranscriptionHIVHIV InfectionsHIV testHIV-1HIV-1 testHIV-2 testHIV-IHIV1HTLV-III InfectionsHTLV-III-LAV InfectionsHortega cellHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHuman immunodeficiency virus 1Human immunodeficiency virus testImmune Cell ActivationImmune PrecipitationImmunoprecipitationIndividualInflammationInflammatoryInflammatory ResponseInnate Immune ResponseIntervening SequencesIntronsLAV-HTLV-IIILife CycleLife Cycle StagesLinkLymphadenopathy-Associated VirusMacrophageMarrow monocyteMediatingMedical centerMicrogliaModern ManModificationMolecularMφNon-Polyadenylated RNANucleotidesPBMCPathway interactionsPeripheralPeripheral Blood Mononuclear CellPersonsPhysiciansPlasmaPlasma SerumPlayProteinsProvirusesPseudouridineRNARNA BindingRNA ExpressionRNA Gene ProductsRNA SeqRNA StabilityRNA and protein interactionRNA boundRNA sequencingRNA-Protein InteractionRNAseqReactive SiteReaderReadingRegimenReportingResearchResolutionReticuloendothelial System, Serum, PlasmaRibonucleic AcidRisk ReductionRoleScientistShort interfering RNASiteSmall Interfering RNATechnologyTestingTissuesTranscriptionViral GenesViremiaVirus-HIVWorkantiretroviral therapyantiretroviral treatmentbasebasesbio-informatics toolbioinformatics toolco-morbidco-morbiditycohortcomorbiditycrosslinkeffective therapyeffective treatmentepitranscriptomicsgitter cellimmune activationinflammation markerinflammatory markerknock-downknockdownlife coursemesogliamicroglial cellmicrogliocytemonocytemutantnano porenanoporenanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingneurocognitive disordernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayperivascular glial cellposttranscriptionalpreventpreventingprotein expressionreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresolutionsrisk-reducingsiRNAsocial rolesystemic inflammationsystemic inflammatory responsetranscriptome sequencingtranscriptomic sequencingviraemiaviral RNAviral sepsisvirus RNAvirusemia
Description preview
PROJECT SUMMARY
People living with HIV (PLWH) on anti-retroviral therapy (ART) still suffer from HIV-associated non-AIDS
complication (HANA) such as neurocognitive disorders. Although chronic inflammation has been thought to be
the driver of HANA, what causes chronic immune activation in PLWH on ART remains unclear. Despite
successful ART,…
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