grant
RNA-mediated gene regulation in the Lyme disease pathogen
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old9 year old9 years of ageAffectAttenuatedB burgdorferiB. burgdorferiBacteriaBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCell LocomotionCell MigrationCell MovementCell divisionCellular MigrationCellular MotilityChildChild YouthChildren (0-21)ComplexDistantEnvironmentEpsilonproteobacteriaFilamentFirmicutesFlagellaGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneHomologGenesGeneticGoalsHomologHomologous GeneHomologueImmune responseInfectionIxodesIxodes tickIxodidaLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMediatingMiceMice MammalsModelingMotilityMurineMusNon-Polyadenylated RNAOrder SpirochaetalesRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRegulationResearchRibonucleic AcidSourceSpirochaetaSpirochaeta genusSpirochaetalesSpirochetesTemperatureTicksUnited StatesVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseWorkage 9 yearsattenuateattenuatesbasal bodycell motilitydiscover genesenzooticepsilon Proteobacteriagene conservationgene discoveryhost responseimmune system responseimmunogenicimmunoresponsekidskinetosomelyme spirochetenine year oldnine years of agepathogentranscriptome sequencingtranscriptomic sequencingvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious diseaseyoungster
Description preview
The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, the most prevalent vector-borne illness in the United States, where children 5 – 9 years old are most commonly affected. Given that B. burgdorferi inhabits tick and mammalian hosts, environments with very different temperatures, immune responses and sources of metabolites,…
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