grant
Riboswitches and their application to RNA visualization and transcription factor interactions with the transcriptome
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY2026AddressAffinityAssayBacteriaBacterial GenesBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBenchmarkingBest Practice AnalysisBindingBioassayBiochemicalBiological AssayBiological FunctionBiological ProcessBiophysicsCell BodyCellsChemicalsCommunicationConsensusDNADeoxyribonucleic AcidElementsGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsHMG-1/-2HMG-BHMG-Box ProteinsHMGBHMGB Family GeneHMGB Family ProteinHMGB ProteinsHigh Mobility Group Box ProteinsImageIn VitroKnowledgeLigand BindingLinkMaintenanceMammalian CellMedicalMessenger RNAMolecularMolecular InteractionMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsNon-Polyadenylated RNAPerformancePropertyProtein FamilyRNARNA BindingRNA Gene ProductsRNA boundReceptor ProteinRegulatory ElementResearchResearch DesignRibonucleic AcidRoleSiteSmall RNASpecificityStructureStudy TypeTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesVirulenceVisualizationanti-microbialantimicrobialaptamerbenchmarkbiophysical foundationbiophysical principlesbiophysical sciencescis acting elementfluorophoreglobal gene expressionglobal transcription profileimagingmESCmRNAmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellneuralnovelpathogenpluripotencypluripotent stateprogramspromoterpromotorreceptorsmall moleculesocial rolestudy designtooltranscription factortranscriptome
Description preview
Project Summary
A broadly distributed means of bacterial gene regulation is an mRNA element called a riboswitch. These
cis-acting elements are found in the 5′-leader regions and regulate expression through their ability to directly
bind a specific cellular metabolite with a highly structured receptor called the aptamer domain. Metabolite binding…
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