grant
Ribonucleotide Stress and Aging
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbscissionAffectAgingCell BodyCellsChemical FractionationChromatinClampingsClosure by clampComplexDNADNA DamageDNA Damage RepairDNA Helicase, RecQ-Like, Type 1DNA HelicasesDNA InjuryDNA RepairDNA ReplicationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA unwinding enzymeDeoxyribonucleic AcidDetectionExcisionExpression SignatureExtirpationFRACNFiberFractionationFractionation RadiotherapyGene Expression ProfileGene TranscriptionGenetic TranscriptionGenomeGenomic DNAGenomicsHumanIn VitroLesionModern ManMolecularNucleic AcidsOutcomePhenotypePositionPositioning AttributeProteasome InhibitorProteinsRECQ Protein-LikeRECQLRECQL geneRECQL1RNA ExpressionRNA NucleasesRNA SeqRNA analysisRNA sequencingRNAseqRNaseRemovalRibonuclease Family ProteinRibonucleasesRibonucleoside PhosphatesRibonucleotidesSpeedStressSurgical RemovalSystemTranscriptionUnscheduled DNA Synthesisage associatedage correlatedage dependentage linkedage relatedage related pathwaysage specificaging associated mechanismaging mechanismaging pathwayaging related mechanismaging related pathwaysbiological mechanism of agebiological pathways of agegDNAgene expression patterngene expression signaturegene functiongenome scalegenome-widegenomewidehelicasemechanism regulating agingmechanisms involved in agingpathway involved in agingreconstitutereconstitutionrepairrepairedreplication stressresectiontranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencing
Description preview
Mis-incorporated ribonucleotides are the most abundant type of genomic lesions, known to disrupt DNA transactions and cause replication stress. However, the mechanism(s) whereby these lesions affect molecular pathways of aging are yet to be examined. In a screen of replicative and DNA repair helicases, we found that RECQL1-catalyzed DNA unwinding…
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